DMT is a chemical neurotransmitter present naturally in the human body as well as in many plants. It can be smoked/vaporized, or used orally which produces very different results. When ingested orally (usually from plant material) it is inactive or weakly active without the addition of an MAO inhibitor. When combined with an MAOI it is then known as Ayahuasca, hoasca, or yage. Pure DMT is most often found in crystal form. The chart below shows smoking dosages for DMT in milligrams (mg). Since the mid 2000s, a smokable form of DMT deposited on plant material that contains MAOIs called "changa" has grown in popularity. Changa requires slightly lower DMT doses and has a somewhat longer duration.

When smoked/vaporized, DMT effects are shortlived and intense and the smoke/vapor is harsh and plastic tasting. Because of the quick onset, users recommend trying to breathe the smoke/vapor in deeply. Waiting too long means the effects may have already begun before the you have an opportunity to take a second.

Many people find the most effective method for smoking/vaporizing DMT is to use a glass pipe and inhale deeply. Often, the DMT melts and some of it remains behind in the pipe. This can be a problem if you load a full dose at a later date and unknowingly have an additional 20 mg left in the pipe. One person has recommended prewarming the pipe. In theory, this will prevent the vaporized DMT from depositing on the cold glass of the pipe. Another suggestion made by some is to put a second screen on top of the DMT so the flame doesn't burn the DMT (resulting in loss of material).

Remember one needs a pretty good scale to weigh the difference between 10 and 50 mg. Be Careful!