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Random Question

Q: I just received some alpha-methyltryptamine, for research purposes, but to my dismay I didn't notice the "methanesulfanate" addition... now, research begins on the 10th, and I am quite concerned as to this slip up on my part. What would the properties of methanesulfanate be in combination with AMT? I have a very bad feeling...

A: Methanesulfonate (not "methanesulfanate"), or mesylate, is a lesser used but common counterion* for salts of amines in drug preparation. Several prescription pharmaceuticals are available as the mesylate salt, such as paroxetine mesylate (Asimia), ergoloid mesylates (Hydergine), and deferoxamine mesylate (Desferal).

While it is possible that the presence of the mesylate could increase the potential toxicity of AMT just by adding extra atoms/groups, the mesylate salt should be no more toxic than other commonly used counterions, such as maleate, tartrate, etc., and there is no clear reason to believe that it would be more toxic than the freebase.

Esters of methansulfonic acid, such as ethyl methanesulfonate, are toxic, but this is not relevant to your question, because the esters should not be present in the material you are asking about.


*a counterion is an ion whose presence allows the formation of an overall neutral charge.

Revision History #

Asked By : Market Troll
Answered By : ALH, Murple, Psilo
Edited By : Spoon, Fire
Published Date : 8 / 5 / 2011
Last Edited Date : 8 / 5 / 2011
Question ID : 2196

Categories: [ Health ] [ AMT ] [ Chemistry ]




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