On Nov 13, 2015, the DEA extended the emergency scheduling of 25I-, 25C-, and 25B-NBOMe by one year, until Nov 2016.

On Nov 15, 2013, the DEA added 25I-, 25C-, and 25B-NBOMe to Schedule I using their emergency scheduling powers, making those NBOMe compounds "temporarily" in Schedule I for two years. It is nearly guaranteed that after two years, these will be permanently added to Schedule I. Having these three chemicals in Schedule I also makes the rest of the NBOMe series probable Controlled Substance Analogues when intended for human consumption. For these three compounds sales, possession, manufacture, and distribution are all crimes under US law.

In June 2013, Erowid was contacted by an individual saying they were being prosecuted under the Analogue Act for distribution of 25I-NBOMe (unconfirmed). In mid 2013, there was an ongoing federal case in the U.S. by the Department of Homeland Security attempting to prosecute 25I-NBOMe under the federal analog act. [erowid private correspondence with defendant]

An informal evaluation by Robert Block of Wisconsin's Controlled Substances Board in September 2011 stated that he believed 25I-NBOMe to qualify as an analog of 2C-I (a Schedule I controlled substance in Wisconsin). "I would like to first make clear that all statements made to your questions are 'MY' opinion and I am neither speaking on behalf of the Wisconsin Crime Laboratories or the Controlled Substances Board (I am the current Chair of CSB). [...] It is my opinion that 25I-NBOMe would qualify as an analog of 2C-I [...]." See drl.wi.gov/board_docview.asp?docid=247&boardid=12&locid=0.

One technical note about 25-*-NBOMe legal status: The primary (easiest) synthetic route for producing 25I-, 25C-, and 25B-NBOMe uses the related controlled substance (2C-I, 2C-C, and 2C-B, respectively) as the precursor chemical. It is likely that NBOMe-compounds sourced from lower-end sources might also contain tiny, detectable amounts of these controlled substance.