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More 5-MeO-DMT Information
by Jonathan Ott (Entheobotanica, 2001).
An excerpt from p.102 of Shamanic Snuffs or Entheogenic Errhines
5-MeO-DMT--Intranasal Psychonautics [MN] I conducted in all six bioassays (MN-I-MN-VI) by way of modeling the Virola snuffs.

With this protocol (MN-I), it was established that 10 mg of [5-MeO-DMT] free-base was the intranasal threshold-dose, evoking a characteristic pharmacodynamic profile for this compound as errhine: first effects at 34 minutes; building to a peak between 3040 minutes; clearly diminishing by 50 minutes; with termination at about 6070 minutes.

MN-II-->MN-V dealt with combinations of b-carbolines with [5-MeO-DMT]. The same 10 mg dose was thus combined with 20, 10 and 5 mg (MN-II, MN-III, MN-IV) harmaline hydrochloride dihydrate (harmaline; 14.9/7.5/3.7 mg harmaline free-base; Acros Organics, Geel, Belgie). In each case, I had significant and dramatic potentiation of this threshold-dose of [5-MeO-DMT], irrespective of the diminishing dosage of harmaline--that is, even the minimal dose was appreciably as effective as the maximal in this regard.

MN-V was a control-experiment insufflating simply 10 mg harmaline (or 7.5 mg base), which provoked no noticeable effects.

For MN-VI I insufflated 5 mg [5-MeO-DMT] with 5 mg harmine hydrochloride dihydrate (harmine; 3.7 mg harmine free-base; Acros Organics), which gave effects commensurate with MN-I (10 mg [5-MeO-DMT] neat)--both b-carbolines roughly doubling the potency of [5-MeO-DMT].