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Excerpt from "Hallucinogens: Neurochemical, Behavioural, and Clinical Perspecives"
edited by B. L. Jacobs.
Raven Press, New York (C) 1984

Medicinal Chemistry and Structure Activity Relationships of Hallucinogens
David E. Nichols and Richard A. Glennon

The 5-hydroxy derrivative of DMT, bufotenine, or N,N-dimethyl-serotonin, is another naturally occuring tryptamine found to occur in South American Snuffs (also Bufo). Intravenours administration of of bufotenine was reported by Fabing and co-workers (59,60) to be hallucinogenic in man. This finding is in conflict with a later report by Turner and Merlis (253). Apparantly, due to its low lipid solubility (65), bufotenine does not readily cross the blood-brain barrier (64,183). The initial observations made by Fabing (59,60) may be the result of peripheral toxic manifestations.

Bufotenine has been found to be behaviourally inactive, or only weakly active in most animals studies...
(Page 123-124)