Citation: froogle. "Unpleasant and I Would Not Repeat It: An Experience with MDMA & Bupropion (exp105567)". Erowid.org. Sep 5, 2019. erowid.org/exp/105567
Most of my research online showed that bupropion would not have much effect on MDMA. I have tried MDMA twice now while taking bupropion, and beg to differ.
I have done MDMA about 10x total in 4 years.
The second to last time was while taking wellbutrin xl at 300mg daily. At the time, I felt the roll was normal, however in retrospect there was less than usual magic. I still felt inhibited, which I never feel while taking MDMA alone.
This most recent time, I was taking wellbutrin at 450mg daily. I took 120mg of crystalline rock MDMA at 11pm by washing down some rocks with water. The come up was slightly longer than usual, about 50 minutes. This is in line with others that have reported the come up is delayed while taking Wellbutrin. Given the appearance, dose, come up time, and bio-assay of others who have taken this substance, I am fairly certain it is pure MDMA.
The roll itself wasn't totally comfortable as is usual. I felt anxious, not nearly as sociable, and more inhibited on the dance floor as a typical roll. I also had difficulty maintaining conversation which is never an issue on MDMA. The peak was not a bad experience, but uncomfortable and not magical by any means.
Usually after having taken clean MDMA I can sleep about 5 hours later if I want. I ate a piece of bread and peanut butter with difficulty at 4am. At 430 am, laying on the couch at home, I realized I wouldn't be sleeping anytime soon so took the opportunity to go for a sunrise hike with friends. Socially I was still somewhat handicapped, whether from the effect of the drugs or lack of sleep I do not know. At 730 I ate half a muffin, again with difficulty. I didn't exactly feel high, but was clearly under the influence still with little appetite even after a night of dancing and a gruelling 1000m vertical hike.
Upon returning home at noon, my eyes were still fully dilated. I slept 3 hours and woke with a headache. The rest of the day was spent watching videos and messing around on Facebook, with little appetite and feeling somewhat worthless. Had some difficulty going to sleep at 11pm, and slept until 9am the next day. Felt functional and improved, but still not great that day.
Given that bupropion is a known dopamine reuptake inhibitor, and MDMA releases dopamine, it is no surprise that the effects of this combination lasted so long. Overall, this experience was unpleasant and I would not repeat it.
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