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Definitely Reduced the Effects
LSD & Antidepressants
by Ethan
Citation:   Ethan. "Definitely Reduced the Effects: An Experience with LSD & Antidepressants (exp111894)". May 11, 2018.

  oral LSD (blotter / tab)
  60 mg oral Duloxetine (daily)
  5 mg oral Pharms - Diazepam (daily)
      Nicotine (daily)


This report will include results of experience of anti-depressant effects on LSD-25, as well as information on a micro-dosing experience.

I am currently on: CYMBALTA 30mg/2x daily, VALIUM 5mg/daily, KLONOPIN 0.5mg-1mg PRN-- usually 1mg per day. (I've been switched between multiple anti-depressants- including Prozac, Escitalopram, Citalopram, Wellbutrin, Remeron, and more- and they all seem to show the same results regarding trips). Also NICOTINE mg?/day.

Personally I have taken LSD too many times to count, but each experience I've been on an anti-depressant. I have NEVER had a bad trip- I am not sure if it is due to the anti-depressants but I view it as positive because I've heard horror stories of bad trips and am glad I've never experienced one. I usually don't take my meds the day I plan on tripping because anti-depressants make the trip 'dulled' so I've heard. Low doses (160g's-200g's) seem to produce the psychedelic feeling unique to the drug class and a decent trip lasting about 6 hours with a sort of uncomfortable comedown that feels like trippy waves that weaken over time.

The highest dose I have taken was recently, and was 450g's (blotter) which exhibited the same feelings as lower doses but with more euphoria during the come-up and slightly more visuals. I exhibit the same traits as described in other reports but with less of a 'magical' aspect and more of an altered sense of reality. The visuals aren't overwhelming, very subtle closed eye visuals, colors and lights are brighter, the carpet seems to be shifting in an indescribable way. Small details get the classical psychedelic trippy twisting movement. Light tracers and a feeling of overall joy. Deeper music connection and I seem to text more/ become more interactive while tripping.

As for micro-dosing, the recommended dose was about 20g's as I've read, but that didn't do anything for me most likely because of my meds, so I doubled it to about 40g's over the course of about a month every other day. I noticed I had more room to think, a more clear mental process, but it just wasn't for me so I discontinued micro-dosing.

OVERALL: Anti-depressants definitely reduce the effects of LSD in comparison to how my friends who are not on prescriptions reacted to similar doses. During a trip I am usually in a trippy state but still able to 'act' sober around others- although I prefer to trip alone.

Also would like to note that this also seemed to apply to Molly, as I did about 200mg in one night and it simply felt like Adderall with a slightly more floaty feeling. However it still caused me to stay up all night. I did not notice an extreme depression after rolling on molly despite what I have read (especially because I have clinical depression I was worried), It was simply a sort of numbed out dull next day.

Exp Year: 2018ExpID: 111894
Gender: Male 
Age at time of experience: 18 
Published: May 11, 2018Views: 1,017
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LSD (2) : Depression (15), Retrospective / Summary (11), Combinations (3), Unknown Context (20)

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