Do you think you might have HPPD?
Take this survey out of University of East London,
which attempts to understand the inner experiences of
people with lasting perceptual changes from use of
psychoactive drugs, (diagnosed or not). It investigates
factors that could create distress or effect quality of life.
Trying a Psychedelic With a Dissociative
Mescaline & Ketamine
by theangrylittlebunny
Citation:   theangrylittlebunny. "Trying a Psychedelic With a Dissociative: An Experience with Mescaline & Ketamine (exp116553)". Jan 14, 2023.

T+ 0:00
200 - 396 mg oral Mescaline
  T+ 4:00 100 mg insufflated Ketamine
  T+ 6:30 100 mg insufflated Ketamine
  T+ 7:30   repeated insufflated Ketamine


I gained a lot of experience with all classes of drugs over the last few years and tried a lot of combinations. But I was always too scared to take a dissociative with a psychedelic. However, recently I decided to do it, because I really wanted to know what it's like because for me psychedelics and dissociatives feel like they are polar opposites.

Recently I managed to make some mescaline from 3,4,5-trimethoxybenzaldehyde and nitromethane I distilled from hobby car fuel. The first time I tried around 150mg of the freebase which was a pretty mild and gentle trip. After that I converted it into the sulfate salt. My second trip was with 275mg of mescaline calculated as the freebase, which is 363mg of the sulfate salt. I took it exactly at midnight so I could easily see how long it has been since I took it. 30 minutes after taking it I already felt slight effects, I laid down in bed, at the one hour mark the effects were quite obvious, with mild visuals and the typical psychedelic body feeling. The effects slowly increased over the next two hours, the visuals got pretty strong but the headspace was quite friendly. Surprisingly, I felt very little nausea during the comeup, much less then I would get from tryptamines like psilocybin and other 4-HO-Tryptamines. I spend the first 5 or 6 hours rolling around in my bed and playing with my blanked while enjoying the nice visuals and the interesting headspace, it was so much fun. After that I listened to music. Overall it lasted about 10 hours. I tried quite a lot of psychedelics, and after this trip I'd say mescaline is my second favourite psychedelic right after ETH-LAD.

After the trip I prepared a capsule with 396mg (300mg based on the freebase), it took a few weeks until I felt like tripping again, but one evening I got myself to do it. I quickly swallowed the capsule so I wouldn't have time to doubt my decision. This time it took much longer to come on. After 45 I felt mild sensations in my body typical for psychedelics. But over the next hour to 90 minutes nothing more seemed to happen, at the 2 hour mark I still felt barely anything. I lied down in my bed and soon I felt some waves of anxiety, it was uncomfortable but not too bad. At that point the effects finally started to really kick in. Over the next few hours it slowly built up and the anxiety faded, but around 4 hours I still was surprised at how weak the effects were, it was much less intense then the 363mg I took before.

I still had 420mg of ketamine, I never took psychedelics with dissociatives, I had psychotic episodes from abusing dissociatives a few years ago and was scared that psychedelic could increase the risk for a psychotic episode. However the trip was so calm and friendly at this point that I decided to take 100mg of ketamine. I weighed out two 50mg doses, poured on of them on my desk and made it into a line. I snorted half of it and after 5 to 10 minutes I started to feel a bit heavy and surprisingly more calm. Over the next 10 to 20 minutes I snorted the remaining 75mg which made me feel more calm and heavy. I was surprised, because I always read that dissociatives make psychedelic trips more intense, but this wasn't the case at all for me.

The effects of the ketamine were kinda in the background of the trip, I still mainly felt the effects of the mescaline. But the ketamine kinda gave me a break when the trip got exhausting. After maybe 40 minutes when the ketamine was wearing off I lied down in my bed, at this point the trip got quite intense, I was probably at the peak at this point. I saw intense visuals around me as well as in my mind, it felt like the psychedelic patterns in my mind were merging with the ones I saw around me. It was really stunning and in my head I just repeated "this is so beautiful, oh my god I love it so much!" I went to the toilet where I noticed that I still was mildly dissociated, after that I lied down in my bed again. Over the next maybe two hours I rolled around in my bed enjoying the visuals and crazy thoughts while playing with my blanket.

Maybe 6 to 7 hours into the trip I decided to take another 100mg of ketamine, which again calmed me down and gave me a break from the trip which was quite exhausting. I lied down in my bed again for maybe an hour.

I had 220mg of ketamine left, so towards the end of the trip, maybe 7 to 8 hours in I decided to use it up so I can explore this combination more. I just poured out some ketamine and snorted it over about an hour. I think I got pretty close to a K-Hole, however the effects of the ketamine still seemed to be kinda in the background of the trip. It made me feel quite calm again and kinda gave me a break from the trip, however my headspace got more twisted and crazy. At one point I had the thought that my mind is the light of the universe, illuminating it with it's consciousness so it can explore it.

This time it took probably over 2 hours for the ketamine to completely wear off. When the effects of the ketamine had mostly subsided the mescaline trip also got close to it's end. The visuals had mostly died down and were quite mild. It was probably 10 to 11 hours after dosing, the trip was still quite friendly, but I was just exhausted and tired of it and wanted it to end. I took 6mg of bromazepam and around 20 minutes later almost all of the psychedelic effects disappeared. I only had very mild visuals which lingered for a few more hours. After that I was just mentally exhausted, so I waited for the lingering effects of the ketamine to wear off and just quickly ate something, after that I went to bed.

One interesting thing I noticed is that I didn't have a hangover from the ketamine, even though I used 420mg in total. Normally when I have a k-hole with 200 to 250mg I feel really exhausted for a day and my tinnitus symptoms would be worse right after the k-hole. However this time I didn't have any of these symptoms, it's the day after now and I don't feel exhausted at all. I read that 5HT2a agonists, which pretty much all psychedelics are protects the brain from the neurotoxic effects of NMDA antagonists like ketamine, so I guess that's why I didn't have a hangover this time. I think I might try combining more dissociatives with different psychedelics, the next is probably gonna be 2C-B. I also might try it with DCK and 2-FDCK at some point.

Exp Year: 2022ExpID: 116553
Gender: Male 
Age at time of experience: 25 
Published: Jan 14, 2023Views: 220
[ View as PDF (for printing) ] [ View as LaTeX (for geeks) ] [ Switch Colors ]
Mescaline (36), Ketamine (31) : Cultivation / Synthesis (31), Combinations (3), Alone (16)

COPYRIGHTS: All reports are copyright Erowid.
TERMS OF USE: By accessing this page, you agree not to download or analyze the report data without contacting Erowid Center and receiving written permission prior to your downloading the data.

Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.

Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults