DOSE: T+ 0:00	14 mg	rectal	7-Hydroxymitragynine	(ground / crushed)
T+ 1:10	4.5 g	oral	Kratom	(ground / crushed)
T+ 2:00	4.5 g	oral	Kratom	(ground / crushed)
T+ 3:00	3 g	oral	Kratom	(ground / crushed)

BODY WEIGHT:

135 lb

Boofing 7-Hydroxy Mitragynine

Dose: 14mg of 7-OH mitragynine, followed by 12g of kratom leaf over two hours
ROA: rectal (suspension in water) and oral
Substance: 7-hydroxymitragynine and Maeng Da kratom leaf from a smoke shop in the USA

tl;dr:
Boofing 14mg of 7-hydroxy mitragynine was not significantly more potent for me than oral administration (both produced negligible levels of intoxication). In addition to this, it did not make either the low range (4.5g) or the high range (12.0g) of my typical kratom dose administered at T+1:10 and T+2:00, respectively, any more intense.

Introduction:
I’ve been using kratom on and off for years, especially during periods where I am otherwise abstinent from all other substances. It’s been an easy alternative to drinking or other drugs, though the reader should be aware that kratom addiction can and does occur. In my case, I have never had withdrawals from kratom and always been able to quit but one could certainly describe my relationship with it as potentially problematic. Granted, it’s never been as problematic for me as other substances and quitting kratom usually means I have started drinking again. I recognize my tendency to replace one addiction for another, and choosing kratom over alcohol or other drugs is a form of harm reduction for me, though if I ever noticed dependence or withdrawals, I would have to reconsider my use of this substance .

Maybe a bit off topic but I want to note that I have never had a habit of taking opioids; I can count the number of times I’ve used them recreationally on one hand. I have snorted ~half of a 30mg Percocet once, I once was prescribed a bottle of codeine cough syrup and unsuccessfully tried to boof half the bottle only to give up and drink the other half, and one time when I was pretty suicidal I bought a blue (read: fake perc-30s, round blue pills stamped with M30, which are all fentanyl) from a guy on the street and smoked it over the course of an evening while on the phone with Never Use Alone. Please don’t do what I did, especially if you (like me) are not an opioid user. I was practically begging to have an overdose. And if you do decide to use opioids alone, especially on a whim, please call Never Use Alone (877-696-1996, https://neverusealone.com/). They’ll sit on the phone with you while you use and send an ambulance if you stop responding.

The closest I’ve come to an opioid habit (kratom is not an opioid, but sort of counts due to its opioid-like effects) was years ago, when I was abstinent except for kratom and had a bad few weeks of forgetting to take my daily bupropion prescription. The irregular antidepressant dosing had wreaked havoc on my mental health. My kratom use shot through the roof to something like an ounce or two a day throughout the day, it was really holding me together. I was fully aware that I was dependent on the kratom due to my whacked-out neurotransmitter condition and that withdrawals were a possibility. When I had finally gotten my shit together and had two weeks of daily antidepressant doses under my belt, I stopped cold turkey and definitely had some mild withdrawal symptoms, so I allowed myself to take an ounce throughout the day (I had taken two ounces the day prior). The next day, I took none and felt fine, glad that I was able to quit without cravings (post-acute withdrawal symptoms or PAWS). Again, the reader should be aware that many people have gotten to this point and been unable to stop so be careful messing around with kratom, it’s not completely innocent. For whatever reason, despite my addictive personality and long relationship with practically every other drug, I have not had a thing for opioids. Your mileage will vary.

Pertinent information:
At time of writing, I have not consumed any other substances or alcohol for over two months and use 4-12g of kratom leaf in a sitting 4+ times per week. The smoke shop I buy my kratom leaf capsules from recently started carrying 7-hydroxymitragynine and I tried it for the first time orally last week. I bought a pack of 3 pills and started with one 14mg pill. I waited an hour without feeling much before taking a second. The second one had positive effects, and so I took the third about half an hour after the second and was a little bit higher than I wanted (along with some nausea but nothing that made me regret the decision. I will likely stick to two pills in the future and titrate with kratom leaf). The pills are prohibitively expensive compared to kratom, even taking the difference in potency into account, and I haven’t found a cheap alternative online. I read that 7-OH mitragynine can convert back to mitragynine up to 45% via hepatic metabolism, so I am going to try boofing a single 14mg pill to observe the effects. I am crushing the pill and mixing it with water before dosing it with an oral syringe, and I am otherwise completely sober and haven’t taken kratom today. I took 8 grams yesterday evening. It is 4:30pm now. I would say that I seem to be developing a tolerance as this 8g did not have the effect it once did, but my first use of 7-OH was recent enough that I think this comparison of ROA is still valid. The objective of this experiment is to see if boofing the pill will make it effective enough that I could use just one pill at a time. I may take some kratom leaf in awhile if this does not have the desired effect, because I want that effect, and because it could show that the 7-OH has made the kratom more potent through stacking.

Experience:
T+0:00. I easily crushed the pill into a fine powder in a makeshift mortar and pestle (I use an acrylic dowel and a ½ oz wide mouth jar, S-17033 from ULINE, these jars come in handy all the time for packing prescriptions on a trip, as a sturdy container for party favors, and as a mortar for crushing and/or mixing stuff up), then added 5ml of warm water before shaking to suspend the powder. I administered this, then added 5mL more of warm water to re-suspend a thick layer of powder which didn’t get drawn into the oral syringe the first time. I’m going to send some emails then play video games.

T+0:10. I think I may feel something, but nothing remarkable. I hazard to say I feel the peripheral “chilled out” vibes and easy focus/enjoyment of work that come with lower doses of kratom but no notable intoxication.
T+0:15. No change. I am going to check in frequently for the first while because boofing usually has a very rapid onset.
T+0:20. Walking and moving revealed a slight effect in my proprioception
T+0:40. Still nothing to write home about, but I have been excitedly adding to the introduction, so I would say there is still that chill vibes feeling.
T+1:10. Still nothing, I would say this experiment was a failure. I am going to take some kratom leaf on top of the boofed 7-OH. I am taking 4.5g of kratom leaf in capsules now.
T+1:30. Not much more, maybe my tolerance is worse than I thought. I’ll wait a bit before taking any more kratom leaf, for science. This is on the bottom end of my usual dose, so it seems like if the 7-OH was helping I might feel this “low” dose.
T+2:00 still nothing. Allow this to add more context for my report, as I would say feeling nothing after 4.5g of kratom leaf and 14mg of 7-OH indicates a tolerance. I am taking an additional 4.5g of kratom leaf. I assume this will cause some sort of effect, but that means nothing about the 7-OH at this point. I’m going to play video games and then check in around T+3:00 to conclude the report.
T+3:00. Definitely feeling it, but still not quite where I want to be. I’ve taken an additional 3g.
T+3:30 I’m where I wanted to be, and I’m going to stop the report here.

Conclusion:
While I thoroughly enjoy 7-OH mitragynine and would rank the experience of taking 3x14mg of it higher than most kratom experiences I have had, its prohibitive cost makes it somewhat inaccessible. My objective was to increase the bioavailability of the 7-OH analog by dosing it rectally so as to avoid first pass liver metabolism, but it did not seem to increase the potency by a meaningful amount. With that said, this experiment was run at a time when I have a higher kratom tolerance than “usual” and it would be interesting to see what effect of boofing 7-OH after I have taken a tolerance break. I am not confident that I understand the pharmacokinetics of mitragynine or this analog, and the issue may not be first pass metabolism. Aside from pharmacokinetics and my tolerance, the other possibility is that the low water solubility of the compound may have made rectal availability lower than is the case for other Drugs I Have Known and Boofed in the past.

Maybe I will take a tolerance break and try this experiment again.

Exp Year: 2024	ExpID: 118316
Gender: Male
Age at time of experience: 29
Published: Aug 31, 2025	Views: Not Supported
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Kratom (203), 7-Hydroxymitragynine (416) : Alone (16), Preparation / Recipes (30), Retrospective / Summary (11), Combinations (3)