DOSE:

Alcohol - Beer/Wine

BODY WEIGHT:

207 lb

Tirzepatide Reduces Alcohol's Euphoric Effects

I am writing this report because GLP-1 agonist lbs are still very new and I haven’t seen much in the way of reports or science that gives any insight into how these drugs interact with other substances. Here’s how one of these drugs, tirzepatide, interacts with alcohol, for me.

I began taking tirzepatide about 8 months ago for weight loss. I've noticed a few interesting effects of the drug. Firstly, it is a miracle drug for weight loss. I have lost 54 pounds so far, with not a single week going by where I haven't lost at least a pound. I am currently 207 lbs, and 5’7” tall. My dosage started at 2.5 mg and was increased gradually to my current dose of 10 mg. Doses are injected IM once per week. Side effects have been mild, and the only negatives so far are lowered blood pressure and occasional dizziness. I have noted that the first four days after taking my weekly dose I tend to have very vivid dreams that involve celebrities, which is notable because I don't follow pop culture or care about celebrities, so it's odd to suddenly start dreaming about them. I've also noticed a pronounced relief of difficulty in getting to sleep that I've suffered with my whole life. Whether these changes are due to the drug I cannot determine definitively, but I felt it was worth noting. In my life I've tried various recreational drugs. The only one that is relevant to this report is alcohol.

With respect to alcohol, I used to be a heavy drinker. As I've gotten older, hangovers just generally aren't worth the experience of the buzz anymore, and over the last five years or so I reached the point where I drink maybe once every couple months, and even then, much less than I used to at any given time. I therefore have no tolerance to alcohol. I do still enjoy drinking on occasion in social circumstances.

At my initial dose of 2.5 mg to about 7.5 mg tirzepatide, I noticed no difference in alcohol’s effects. At around 7.5 mg, I noticed that the buzz was less pronounced for a while and had a delay in kicking in. This led to me on a couple of occasions drinking more to experience the buzz, and then finding myself quite intoxicated once the delayed effect kicked in.

After moving to 10 mg tirzepatide recently, alcohol seems to have no euphoric effect. I began to notice this on a recent three-day road trip, and in the evenings to unwind my wife and I would have a couple beers or some wine. I could not feel the effects of alcohol from 2 to three beers or glasses of wine throughout the trip.

Last weekend my wife and I opened a bottle of champagne. I drank half of it in about 30 minutes. It produced no euphoric effect at all. I then drank 3 ales at about 6.5% alcohol within the next hour or so. I experienced no euphoric effect. I did experience some mild reduced motor control, but otherwise felt completely sober. Interestingly, the next day I had a minor hangover for a few hours. The amount of alcohol I drank would typically have given me a substantial and unpleasant hangover in the past. The hangover indicates that my body was breaking down the alcohol, but for whatever reason I can’t lot experience any of the euphoric, pleasant effects.

I don’t know if drinking stronger alcohol like whiskey, and drinking it faster, might have produced an effect. I am reluctant to try because of the delayed reaction effect I experienced earlier. I don’t know the mechanism behind this, but I do know that drinking alcohol while taking tirzepatide could be potentially dangerous to others who experience this inhibited euphoria. It could cause one to drink possibly dangerous amounts of alcohol, or at least more than one might intend, and end up much more intoxicated than intended if the alcohol eventually kicks in. It could also lead one to underestimate their level of intoxication because they could feel completely sober when motor control is still quite impaired – it could be easy to miss the motor control impairment.

For me, it essentially means I am now a non-drinker because there is no longer any fun in doing it.

Exp Year: 2024	ExpID: 118586
Gender: Male
Age at time of experience: 47
Published: Sep 15, 2025	Views: Not Supported
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Alcohol - Beer/Wine (199) : Retrospective / Summary (11), Combinations (3), Small Group (2-9) (17)