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Unexpected Panic from Small Dose
Cyclobenzaprine
Citation:   Famous Actress . "Unexpected Panic from Small Dose: An Experience with Cyclobenzaprine (exp119122)". Erowid.org. Aug 19, 2025. erowid.org/exp/119122

 
DOSE:
T+ 0:00
36 mg oral Pharms - Methylphenidate (pill / tablet)
  T+ 7:00 2.5 mg oral Pharms - Cyclobenzaprine (pill / tablet)
  T+ 7:00 2 tablets oral Acetaminophen (pill / tablet)
  T+ 0:00 2.5 mg oral Pharms - Cyclobenzaprine (pill / tablet)
  T+ 0:00 20 mg oral Pharms - Escitalopram (daily)
  T+ 33:00 2.5 mg oral Pharms - Cyclobenzaprine (pill / tablet)
BODY WEIGHT: 135 lb
I could not find any specific stories online regarding this kind of experience. A few days ago I took a very small dose of cyclobenzaprine and had a major panic attack and derealization episode that lasted about four days.

I was initially prescribed the muscle relaxer five years for some neck issues that were contributing to my migraines. The doctor prescribed 5 mg twice a day everyday for 2 weeks. I remember it being so strong I took it for a few days but couldn’t keep my eyes open so stopped and just took when I had bad tension. Before, it felt strong in the sense of extreme drowsiness, not like what I am about to describe. I have since found a combination that works for the migraines, but still have the occasional breakthrough and tension headache. I hadn’t needed the muscle relaxer in a few years so I got it refilled last week.

On Saturday, I had a seven hour drive to my friend’s bachelorette party. I took my 36mg concerta at 7 in the morning to focus and around halfway through the drive my head started to pound. I took some Tylenol at noon and kept it moving. I was planning on taking half of the muscle relaxer once I arrived. When I got there I was in a lot of pain but did not have any time to chill out, so I ate a little, took a half, and two more Tylenols. A few hours later I was still hurting so I took the other half of the muscle relaxer (5 mgs in total). I was very pleasantly relaxed and almost felt a little stoned. Not sure if that was from the drive, exhaustion or what. All was well and I took my lexapro before bed. By bedtime I felt totally normal and decently relaxed. Ok great so I’m thinking the meds are fine.

The next day I woke up in pain again. I really wanted to knock it out so I could make sure the bride had a great time with all of us. I was not going to let myself sit out on any of the activities since we were only there for a weekend. Anyways, the afternoon comes and I decided to take another half of the muscle relaxer (2.5 mgs at 4 pm). Also, I don’t drink at all and hadn’t taken the concerta this day. Only a cup of coffee. I start to get ready for dinner and at 4:45 the shift happened.

I was looking in the mirror putting on my makeup and I feel super high and see my pupils dilate.
I was looking in the mirror putting on my makeup and I feel super high and see my pupils dilate.
I was like okay weird I’m a little high but probably just hungry or something. I don’t have anything to compare the “high” to but maybe something in the opiate family? Then it kept getting more intense to the point where I was questioning if I accidentally took two. I had only brought 2 with me and saw that there was one still cut in half. The waves of panic started to hit and they wouldn’t stop. Left arm tingling, chest tight, was only able to get in a shallow breaths, and super dizzy. Felt like I was nodding out. Something felt really wrong but at this point I’m stuck in a car on the way to dinner.

Once we arrived at the restaurant I ran in and told everyone I just need to use the bathroom really bad. I was too embarrassed to admit I was losing my mind over half of a pill. We sat down for dinner and I’m still tweaking. Started to get paranoid that the food was poisoned. All kinds of weird stuff. This went on for a few hours and the panic eventually stopped. Even then for the next few days I felt super out of it- detached from my body, not real, and super paranoid about people being out to get me.

Thankfully after 5 days I’m back to baseline.
Thankfully after 5 days I’m back to baseline.
Still anxious but in a way that I can manage and feel grounded. Still confused how I never had the side effect when I took this years ago or even the day before when I was fine. Still looking for an answer.

Lesson learned- do NOT take a muscle relaxer before your friends bachelorette dinner.

Exp Year: 2025ExpID: 119122
Gender: Female 
Age at time of experience: 28
Published: Aug 19, 2025Views: Not Supported
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Pharms - Cyclobenzaprine (267) : Combinations (3), Difficult Experiences (5), Various (28)

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