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Serotonin Syndrome
Tramadol & Escitalopram (Lexapro)
by sick girl
Citation:   sick girl. "Serotonin Syndrome: An Experience with Tramadol & Escitalopram (Lexapro) (exp34829)". Erowid.org. Aug 19, 2004. erowid.org/exp/34829

 
DOSE:
10 mg oral Pharms - Escitalopram (daily)
  150 mg oral Pharms - Tramadol (pill / tablet)

BODY WEIGHT: 108 lb


This is a warning! I take Lexapro (escitalopram oxalate), an SSRI prescribed for depression. SSRI is a Selective Serotonin Reuptake Inhibitor: it increases the levels of serotonin in your brain to reduce depression symptoms. This medicine has been VERY effective in curing my depression. The problem is, I have a long history of Tramadol abuse, which started when I was hospitalized about a year ago and was given it for pain.
I had been taking Lexapro for about 3 weeks when I stupidly decided to indulge in some Tramadol. I only took 150mg (i usually take about 200-250).

The high was one of the best ones I've ever had, but that's not my point. The problem came the next evening, when I woke up in the middle of the night feeling really, REALLY, REALLY sick. I started shivering and in 3 seconds my ENTIRE BODY sweat so fast that I became completely soaked. I had diarrhea and threw up at the same time. I screamed for help and told my husband I was going to die. It is hard to describe how horrid of and experience that was. If you know what a bad trip on ecstasy is, (Iíve had one), multiply it by 100 and you have an idea of what I'm talking about.
I survived. The next day I did some research online on Tramadol interaction with SSRI and found out I had Serotonin Syndrome, an excess of serotonin in the brain that can be FATAL, so I DID almost die that night.

Exp Year: 2004ExpID: 34829
Gender: Female 
Age at time of experience: Not Given 
Published: Aug 19, 2004Views: 62,071
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Pharms - Escitalopram (304), Pharms - Tramadol (149) : Combinations (3), Post Trip Problems (8), Health Problems (27), Not Applicable (38)

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