It Is a Nice Relaxing Feeling
Duloxetine
Citation:   Duloxetine/Cymbalta. "It Is a Nice Relaxing Feeling: An Experience with Duloxetine (exp41408)". Erowid.org. May 29, 2018. erowid.org/exp/41408

 
DOSE:
  oral Duloxetine (daily)
BODY WEIGHT: 160 lb
Duloxetine first time

I started taking Duloxetine for pain I have (fibromyalgia). At the first week starting dosage of 30mg/day it didn't seem to do a whole lot. But the first few days of the 60mg/day dosage felt like the aftereffects of an Ecstacy trip. I noticed I felt kinda funny the first morning and then my girlfriend said that my eyes were all dilated.

It is a nice relaxing feeling, but definitely feels somewhat speedy. It is the type of thing where I am trying to decide if it is good or bad...and then finally decide that it is a bit of both.

Also, I tried to chew up just a few (<10) of the pellets inside the capsule and it made my tongue numb for quite a while. I think crushing up a whole capsule would be very unpleasant.

It also seems to make hydrocodone somewhat less effective. I think this is because it moderately inhibits CYP2D6, which is the enzyme that metabolizes hydrocodone.

Exp Year: 2005ExpID: 41408
Gender: Male 
Age at time of experience: Not Given
Published: May 29, 2018Views: 7,276
[ View PDF (to print) ] [ View LaTeX (for geeks) ] [ Swap Dark/Light ]
Duloxetine (395) : General (1), Retrospective / Summary (11), Medical Use (47), Therapeutic Intent or Outcome (49), Not Applicable (38)

COPYRIGHTS: All reports copyright Erowid.
No AI Training use allowed without written permission.
TERMS OF USE: By accessing this page, you agree not to download, analyze, distill, reuse, digest, or feed into any AI-type system the report data without first contacting Erowid Center and receiving written permission.

Experience Reports are the writings and opinions of the authors who submit them. Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.


Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults