DOSE:

oral

Duloxetine

(daily)

BODY WEIGHT:

160 lb

Duloxetine first time

I started taking Duloxetine for pain I have (fibromyalgia). At the first week starting dosage of 30mg/day it didn't seem to do a whole lot. But the first few days of the 60mg/day dosage felt like the aftereffects of an Ecstacy trip. I noticed I felt kinda funny the first morning and then my girlfriend said that my eyes were all dilated.

It is a nice relaxing feeling, but definitely feels somewhat speedy. It is the type of thing where I am trying to decide if it is good or bad...and then finally decide that it is a bit of both.

Also, I tried to chew up just a few (<10) of the pellets inside the capsule and it made my tongue numb for quite a while. I think crushing up a whole capsule would be very unpleasant.

It also seems to make hydrocodone somewhat less effective. I think this is because it moderately inhibits CYP2D6, which is the enzyme that metabolizes hydrocodone.

Exp Year: 2005	ExpID: 41408
Gender: Male
Age at time of experience: Not Given
Published: May 29, 2018	Views: 7,276
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Duloxetine (395) : General (1), Retrospective / Summary (11), Medical Use (47), Therapeutic Intent or Outcome (49), Not Applicable (38)