Citation: anationof1. "To End Any Psychedelic Trip: An Experience with (Quetiapine) Seroquel (exp50777)". Erowid.org. Apr 6, 2006. erowid.org/exp/50777
I have noticed, over the past few years, that one twenty-five milligram dose of Seroquel (Quetiapine) can completely end any psychedelic trip. That can be if I am having a bad trip, or simply want to sleep and cannot. Seroquel appears to have some sort of dopaminergic/serotinergic blocking abilities, as it slowly but surely will diminish most of the effects of whatever I've taken, until all I can feel is the sedative effects of the pill. It is an antipsychotic, and while it's much more safe than Risperidone and other more old-fashioned antipsychotics in terms of long-term effects, I limit use of it to when it's absolutely necessary. It WILL make me sleep, that is pretty much guaranteed.
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