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Lessening of Cravings and Euphoria
Bupropion (Wellbutrin) & Opiates
by Aria
Citation:   Aria. "Lessening of Cravings and Euphoria: An Experience with Bupropion (Wellbutrin) & Opiates (exp75361)". Oct 6, 2009.

200 mg oral Pharms - Bupropion (daily)
    repeated   Opiates  
I was recently prescribed bupropion 100 mg to be taken twice a day for depression. Prior to this I have been using opiates, particularly black tar heroin and oxycodone, nearly everyday for the past 6 months. I experience major opiate withdrawal approx 24 hours after last administered dose.

However, once I began taking bupropion (Wellbutrin) I noticed that I no longer got high when ingesting opiates. Interestingly, since I began taking bupropion I have had minimal opiate withdrawal. Also, I've noted that insufflated doses are more effective than ingested doses (particularly with oxycodone). I would say 60 mg ingested oxycodone had about a quarter of the effect it normally would, whereas insufflation would be 50-75% typical effect. In both cases bupropion inhibited the opiate's positive effect.

I haven't seen any other reports about combining these two substances (and I researched rather intensively) so I hope this will shed some light on the issue. I now stopped taking opiates altogether due to a lessening of craving and a lessening of euphoria as a result of the bupropion.

Exp Year: 2008ExpID: 75361
Gender: Male 
Age at time of experience: Not Given
Published: Oct 6, 2009Views: 26,452
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Pharms - Bupropion (87), Opiates (207) : Health Benefits (32), Combinations (3), Not Applicable (38)

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