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Looking Back
4-methylmethcathinone (Mephedrone)
by Doomknot
Citation:   Doomknot. "Looking Back: An Experience with 4-methylmethcathinone (Mephedrone) (exp85916)". Sep 24, 2010.

T+ 0:00
100 mg oral 4-Methylmethcathinone (capsule)
  T+ 0:15 50 mg oral 4-Methylmethcathinone (capsule)
  T+ 1:30 100 mg oral 4-Methylmethcathinone (capsule)
  T+ 3:30 3 ml oral GHB (liquid)
  T+ 3:30 0.25 mg oral Pharms - Alprazolam (pill / tablet)
  T+ 3:30 25 mg oral Diphenhydramine (pill / tablet)
  T+ 3:30 2 hits inhaled Cannabis  
  T+ 5:30 2 ml oral GHB (liquid)
  T+ 5:30 50 mg oral Dimenhydrinate (pill / tablet)


The following presents a retrospective of my first few trials with 4-Methylmethcathinone (a.k.a. and henceforth called, Mephedrone). Here is a brief summary of the effects that I experienced:

Positive: Elevated mood; mild euphoria; empathogenic effects; mild to moderate stimulation; increases in motivation, sociability and mental clarity; no notable come-down or hangover; aphrodisiac after come-down.
Neutral: Slightly raised heart rate; pupil dilation; chattiness; appetite suppression.
Negative: Difficulty sleeping after primary effects had subsided.

I received 10 grams from a reputable online chemical supplier. Since the deaths that occurred last year resulting from the mislabeling of a batch of Bromo-Dragonfly as 2C-B-Fly, Iíve been much more careful handling new chemical samples. A series of increasing, low dose trials can be a very effective approach to keeping oneself reasonably safe, as follows:

I began by insufflating 1 mg, the rational being that even if the package were mislabeled and the substance was actually one of the most active research chemicals such as Bromo-Dragonfly or DOI, the result might be very uncomfortable, but wouldnít likely be life-threatening. No effects whatsoever were experienced at this dose.

A second dose of 5 mg was insufflated one half hour later. No effects were noted.

One hour later, a third dose of 25 mg was insufflated in two equal parts (lines) taken approximately one half hour apart. One hour after the first 12.5 mg line was taken, I felt an energetic lift, I was talkative and very clear headed with improved conversational ability. No significant physical effects were present. This experience gradually tailed off, with no ill comedown noted. At this point, since the substance was presenting itself exactly as expected, I felt confident that the package was accurately labeled and I could move on to a full dose.

One week later:

We were planning to attend a house party on the weekend, and decided it might be a good venue for our first full trial. After reading various trip reports online and studying the various doses and responses, we decided weíd take multiple doses, up to a maximum total of 300 mg each. We prepared 2 Ė 100 mg capsules and 2 Ė 50 mg capsules for each of us, to be taken over the course of the evening.

T=0:00 (9:50 PM) Ė We each took a 100 mg capsule on the way to the party, and then an additional 50 mg capsule 15 minutes later, just before entering the house. We thought this approach might smooth and slow the come up, and reduce the chance of gastrointestinal upset or being caught up in a strong rush upon arrival.

T+0:20 Ė Despite not knowing anyone at the party, we settled in quickly and easily. We were both feeling first alerts: lightly stimulated, slightly euphoric and sitting in the back yard around a small camp fire feeling very sociable. There wasnít any strong rush or queasiness that sometimes comes from the onset of MDMA, a much compared substance.

T+0:45 Ė I am feeling really good and I think the substance is nearing the peak. The party is unfolding in a beautiful urban back yard, surrounded by lush gardens and trees decorated with white mini-lights. Socializing is smooth and easy. I feel friendly, loving and outgoing, without feeling over-stimulated. My partner is not feeling as much as I am at this point.

T+1:15 Ė Yes! I feel great. I feel lucid, socially competent, and very at ease. My mind is nicely tweaked, but my body feels mostly normal. Heart rate is only slightly elevated, body temperature feels more or less normal. The party is filling up, and very warm, considerate, outgoing people dominate the scene.

T+1:30 Ė Hark! Is that the first hint of drop-off I feel? Yes, I think I have just crested the peak and begun the descent ... time to re-dose! I take another 100 mg, but I canít find my partner. I find her about 10 minutes later and give her 100 mg. Fifteen minutes after that, we cross paths again, and she indicates she has yet to experience a very strong effect, so I suggest she takes her remaining 50 mg, bringing her total to 300 mg. She agrees. I decide to stick at 250 mg.

T+1:50 Ė At this point my second dose hasnít taken hold yet, and I am feeling like I am on my way down from the first dose. I feel less wonderful than I did, but still quite nice. We go inside the house to dance while the second phase takes hold.

T+2:00 - Dancing is fun and feels good, but I donít have a great deal of energy, so after a song or two, we go back outside to the patio. My second dose is clearly coming up, and my partner is finally feeling this substance blossom into something quite noteworthy.

T+3:00 Ė Weíre both feeling fantastic, very sociable, and agree this is one hell of a substance. It is not as physically prominent as say MDMA or Methylone, but it provides a very wonderful mood lift. I feel completely in control, at ease, content.

T+3:30 Ė Iíve reached the tail end of the second peak, and we decide itís time to go home. Arriving home, we still feel quite stimulated so we take 3 ml of GHB, 0.25 mg of Xanax, 25 mg diphenhydramine and some vapour hits of weed, hoping to bring on sleep quickly. We sit around and talk about the evening for an hour or so, and finally crawl in to bed.

T+5:30 (3:20 AM) Ė We're both incessantly tossing and turning. I realize this substance shares a quality with Methylone, that being, extreme horniness after come-down. Not only am I still very stimulated despite the onslaught of sedatives, but my mind is filled with erotic fantasies that are making it impossible to sleep. My partner says her heart is still beating quite fast. Mine feels normal. She suggests we have sex to alleviate my horniness, but Iím actually too exhausted at this point to accept the offer! We go back downstairs for another 2 ml of GHB each, and I have 50 mg of dimenhydrinate as well. Shortly after, the sexual fantasies give way to dreamy visions and I finally fall asleep, albeit pretty fitfully, and I feel pretty tired when we woke the next day.


What a great experience! I have to say I am thoroughly excited about this compound, because itís been a while since something interesting has come on the market. If I were to paint Mephedrone with a broad brush, Iíd say it sits somewhere between Ritalin and Methylone. Or, if Methylone could be considered ĎMDMA lightí, then I might describe Mephedrone as ĎMethylone lightí. Itís less empathogenic and physical than Methylone, but it definitely had notable heart-opening qualities. I think it could be a light and effective medicine for use in relationship therapy, apparently with sex being a reasonable post-session prospect.

Recreationally, as a gentle social elixir it might just be about as good as it gets. I tend to get a bit too chatty on MDMA and Methylone, and every once in a while I wake up after a party feeling like I was a bit too friendly and gushy. Ritalin can make me look and feel like a tweaker. Mephedrone allowed me a bit more restraint, and I liked that. Most of all, I liked the fact that there was virtually no crash. I felt crappy the next day, but it just felt like a lack of sleep.

Regarding the substance duration, it was very short, and so I felt a bit of a roller coaster effect with the dosing strategy we used. Next time I will probably take the same total amount, but in repeated smaller doses, to get a more consistent effect over time; a sort of extended release plan if you wish (ask your doctor if Mephedrone ERģ is right for you ... hehe). I think starting with 100 mg, then taking 50 mg capsules every 45 minutes over 2.5 hours might work well. Or as an alternative, Iíll dissolve 250-300 mg in a bottle of juice, and sip on it over the course of an evening (Report update: since writing this report, I tried this dosing method and it worked very, very well!).

My total dose of 250 mg was perfect for me. For my partner, 300 mg was perfect, despite being only 75-80% of my body weight. We both agreed we started a bit too late in the night, and would rather not still have been speeding at 2:30 AM. There is no question, this substance left us with a great deal of residual stimulation.

There is a lot of online discussion regarding addiction and habituation. This substance left me excited at the prospect of doing it again, but Iím not one that falls prey to impulse so much. I can definitely see the habituation potential, but remember folks ... there are no bad drugs, only bad usage patterns. Used cautiously and sensibly, I think Mephedrone is a very worthy substance.

Notes on Insufflation:

I insufflated Mephedrone a couple of times in 30 and 40 mg doses and found it very effective. The only negative side effect was the burn, which was formidable. The duration didnít seem too greatly effected, although it was reduced somewhat, and given that the oral duration is already so short, Iím not overly inclined to use this method, unless I only want a very small bump to get me moving at a party.

Notes on smoking/vaporizing:

I tried smoking/vaporizing Mephedrone a couple of times, in 20 mg doses, using a small glass bulb pipe and an indirect flame. First I tried using a cannabis vaporizer, but the 500 degree maximum setting was insufficient to vaporize the material. I found the effects to be similar to insufflation. The first hit was very clean and nice tasting, almost nutty, but what worries me, is that after it melted down and went golden, it became markedly more harsh, making me wonder if the heat converts it to something else. My throat felt slightly irritated for an hour or two afterward, as if I had gone jogging in cold weather. The next day, I coughed up small amounts of clear phlegm. Needless to say, I donít imagine Iíll be doing that again. If Iím looking for rapid effects, itís far easier to insufflate it.

Thanks for reading. I hope this provided a solid overview: one personís experiences anyway!

Exp Year: 2010ExpID: 85916
Gender: Male 
Age at time of experience: Not Given 
Published: Sep 24, 2010Views: 22,097
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4-Methylmethcathinone (458) : Various (28), Therapeutic Intent or Outcome (49), Performance Enhancement (50), Sex Discussion (14), Glowing Experiences (4), Retrospective / Summary (11), First Times (2)

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