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Olanzapine (Zyprexa)
by Erowid
Caution :   Reactions and experiences may vary dramatically from person to person. [see below]
  • Reduction in psychotic symptoms
  • Potential antidepressant effect
  • Reduction in anxiety
  • Euphoria
  • Blurred vision
  • Dry mouth
  • Agitation, anxiety
  • Akathisia (restless leg)
  • Dizziness
  • Insomnia
  • Weight gain
  • Sedation
  • Chest Pain, Hypotension, Tachycardia
  • Constipation
  • Joint Pain
  • Loss of Interest in Sex, occasional impotence in men
Pharmacology / Mechanism of Action
The mechanism of olanzapine is unknown, however it is hypothesized that its actions are mediated through a combination of serotonin type 2 (5-HT2) and Dopamine type 2 (DA-2) antagonism. Antagonism at other receptors may explain the side effects observed with olanzapine. Antagonism at histamine type 1 may explain the somnolence observed with this drug. Antagonism at muscarinic 1-5 receptors may explain the anticholinergic effects of olanzapine. Antagonism at alpha type 1 adregenic receptors may explain the orthostatic hypotension associated with olanzapine. Antagonism of muscarinic, histaminic H1 and alpha1-adrenergic receptors also possible.

Erowid's effects information is a summary of data gathered from users, research, and other resources. This information is intended to describe the range of effects people report experiencing. Effects may vary dramatically from one person to another or one experience to another based on a variety of factors such as body chemistry, age, gender, physical health, dose, form of material, etc.