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MATERIAL SAFETY DATA SHEET
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OCCUPATIONAL HEALTH SERVICES, INC. FOR EMERGENCY SOURCE INFORMATION
11 WEST 42ND STREET, 12TH FLOOR CONTACT: 1-615-366-2000
NEW YORK, NEW YORK 10036
1-800-445-MSDS (1-800-445-6737) OR
1-212-789-3535
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SUBSTANCE IDENTIFICATION
CAS NUMBER: 1972-08-3
RTECS NUMBER: HP8225000
SUBSTANCE: TETRAHYDROCANNABINOL
TRADE NAMES/SYNONYMS:
6H-DIBENZO(B,D)PYRAN-1-OL, 6A,7,8,10A-TETRAHYDRO-6,6,9-TRIMETHYL-3-
PENTYL-, (6A(R)-TRANS)-;
(6A(R)-TRANS)-6A,7,8,10A-TETRAHYDRO-6,6,9-TRIMETHYL-3-PENTYL-6H-
DIBENZO(B,D)PYRAN-1-OL;
CANNABINOL, DELTA-1-TETRAHYDRO-; (L)-DELTA-1-TETRAHYDROCANNABINOL;
TRANS-DELTA-9-TETRAHYDROCANNABINOL; DELTA-1-TETRAHYDROCANNABINOL;
DELTA-9-TETRAHYDROCANNABINOL; THC; DELTA-1-THC; DELTA-9-THC; C21H30O2;
OHS23005
CHEMICAL FAMILY:
POLYCYCLIC, HETERO
MOLECULAR FORMULA: C21-H30-O2
MOLECULAR WEIGHT: 314.45
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=1
NFPA RATINGS (SCALE 0-4): HEALTH=3 FIRE=1 REACTIVITY=0
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COMPONENTS AND CONTAMINANTS
COMPONENT: TETRAHYDROCANNABINOL PERCENT: 100.0
CAS# 1972-08-3
OTHER CONTAMINANTS: NONE
EXPOSURE LIMITS:
NO OCCUPATIONAL EXPOSURE LIMITS ESTABLISHED BY OSHA, ACGIH, OR NIOSH.
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PHYSICAL DATA
DESCRIPTION: SOLID. BOILING POINT: 392 F (200 C) @ 0.02 MMHG
MELTING POINT: NOT AVAILABLE SPECIFIC GRAVITY: NOT AVAILABLE
SOLUBILITY IN WATER: NOT AVAILABLE
SOLVENT SOLUBILITY: SOLUBLE IN ETHANOL.
1 OHS23005 PAGE 002 OF 006
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FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
SLIGHT FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME.
FIREFIGHTING MEDIA:
DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FIREFIGHTING:
MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO IT WITHOUT RISK (1990 EMERGENCY
RESPONSE GUIDEBOOK, DOT P 5800.5, GUIDE PAGE 53).
EXTINGUISH USING AGENT SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BREATHING
VAPORS AND DUSTS. KEEP UPWIND.
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TOXICITY
TETRAHYDROCANNABINOL:
TOXICITY DATA: 666 MG/KG ORAL-RAT LD50; 482 MG/KG ORAL-MOUSE LD50; 525 MG/KG
ORAL-DOG LDLO; 29 MG/KG INTRAVENOUS-RAT LD50; 42 MG/KG INTRAVENOUS-MOUSE
LD50; 128 MG/KG INTRAVENOUS-MONKEY LDLO; 373 MG/KG INTRAPERITONEAL-RAT
LD50; 168 MG/KG INTRAPERITONEAL-MOUSE LD50; REPRODUCTIVE EFFECTS DATA
(RTECS); MUTAGENIC DATA (RTECS); TUMORIGENIC DATA (RTECS).
CARCINOGEN STATUS: NONE.
ACUTE TOXICITY LEVEL: MODERATELY TOXIC BY INGESTION.
TARGET EFFECTS: CENTRAL NERVOUS SYSTEM DEPRESSANT. POISONING MAY ALSO AFFECT
THE RESPIRATORY, CARDIOVASCULAR AND IMMUNE SYSTEMS.
ADDITIONAL DATA: THE USE OF ALCOHOLIC BEVERAGES MAY ENHANCE THE TOXIC EFFECTS.
POISONING MAY IMPAIR THE PERFORMANCE OF TASKS REQUIRING ALERTNESS.
INTERACTIONS WITH MEDICATIONS HAVE BEEN REPORTED.
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HEALTH EFFECTS AND FIRST AID
INHALATION:
TETRAHYDROCANNABINOL:
NARCOTIC.
ACUTE EXPOSURE- SINCE TETRAHYDROCANNABINOL IS AN ACTIVE INGREDIENT IN
MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
INHALATION OF MARIJUANA SMOKE MAY IRRITATE MUCOUS MEMBRANES CAUSING
DRYNESS, HOARSENESS AND BRONCHODILATION. RHINITIS, PHARYNGITIS AND ASTHMA
MAY ALSO OCCUR ACUTELY, BUT ARE MORE COMMON AFTER CHRONIC EXPOSURE.
SYSTEMIC EFFECTS MAY OCCUR AS DETAILED IN ACUTE INGESTION.
CHRONIC EXPOSURE- SNIFFING MARIJUANA MAY CAUSE AN ULCERATED OR PERFORATED
NASAL SEPTUM. REPEATED SMOKING MAY RESULT IN COUGH, LARYNGITIS,
BRONCHITIS, OTHER RESPIRATORY EFFECTS AS IN ACUTE INHALATION AND
PULMONARY FUNCTION IMPAIRMENT. LONG-TERM USE BY HUMANS AND EXPERIMENTAL
ANIMALS HAS LEAD TO SQUAMOUS METAPLASIA OF THE TRACHEAL MUCOSA. SYSTEMIC
EFFECTS MAY OCCUR AS DETAILED IN CHRONIC INGESTION. REGULAR CHRONIC USE
MAY RESULT IN REPRODUCTIVE EFFECTS IN MALES INCLUDING DECREASED TESTICULAR
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SIZE, TESTOSTERONE LEVELS, SPERM COUNT AND MOTILITY AND ABNORMALITIES
IN SPERM. GYNECOMASTIA MAY DEVELOP WITH HEAVY USE. FEMALES MAY EXPERIENCE
A HIGH FREQUENCY OF ABNORMAL PERIODS, LESS OVULATION AND DECREASED
PROLACTIN LEVELS. REPRODUCTIVE EFFECTS HAVE ALSO BEEN REPORTED IN
ANIMALS.
FIRST AID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY. IF BREATHING
HAS STOPPED, PERFORM ARTIFICIAL RESPIRATION. KEEP PERSON WARM AND AT REST.
TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION IMMEDIATELY.
SKIN CONTACT:
TETRAHYDROCANNABINOL:
ACUTE EXPOSURE- NO DATA AVAILABLE.
CHRONIC EXPOSURE- APPLICATION OF "TAR CANNABIS" RESIDUALS TO ANIMAL SKIN
RESULTED IN TUMOR PRODUCTION.
FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY. WASH AFFECTED
AREA WITH SOAP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO
EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL
ATTENTION IMMEDIATELY.
EYE CONTACT:
TETRAHYDROCANNABINOL:
ACUTE EXPOSURE- SINCE TETRAHYDROCANNABINOL IS AN ACTIVE INGREDIENT IN
MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
SYSTEMIC ADMINISTRATION OF MARIJUANA MAY CAUSE PURPLE-YELLOW VISION,
HYPEREMIA OF THE CONJUNCTIVA, PUPIL DILATION, SLOW REACTION TO LIGHT AND
DIPLOPIA.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER OR NORMAL SALINE,
OCCASIONALLY LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL
REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY.
INGESTION:
TETRAHYDROCANNABINOL:
NARCOTIC.
ACUTE EXPOSURE- SINCE TETRAHYCROCANNABINOL IS AN ACTIVE INGREDIENT IN
MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
INGESTION OF LOW TO MODERATE AMOUNTS OF MARIJUANA MAY CAUSE RELAXATION,
EUPHORIA, AN ALTERED TIME AND SPACE PERCEPTION, VIVID OLFACTORY, AUDITORY
AND VISUAL SENSES, DISORIENTATION, AND SLEEP, VISUAL AND BODY IMAGE
DISTURBANCES. INFORMATION LEARNED WHILE INTOXICATED MAY BE POORLY
RECALLED. DIFFICULTY WITH COGNITIVE FUNCTIONS SUCH AS SPEECH AND
ORGANIZATION OF THOUGHTS MAY BE ASSOCIATED WITH IMPAIRED SHORT TERM
MEMORY. PSYCHOMOTOR PERFORMANCES MAY ALSO BE IMPAIRED. OTHER EFFECTS MAY
INCLUDE DRY MOUTH AND THROAT, HEADACHE, NAUSEA, VOMITING, WEAKNESS,
RESTLESSNESS, TINNITUS, APPETITE STIMULATION POSSIBLY DUE TO
HYPOGLYCEMIA, TREMOR, DELIRIUM, JOCULARITY, STUPOR, ATAXIA, DEPRESSION,
AGGRESSIVENESS AND PARESTHESIAS. RESIDUAL SEDATION MAY PERSIST THE
FOLLOWING DAY. POSSIBLE CARDIOVASCULAR EFFECTS INCLUDE HYPERTENSION OR
HYPOTENSION, SINUS TACHYCARDIA AND PREMATURE VENTRICULAR CONTRACTIONS.
LARGE DOSES MAY LEAD TO DEPERSONALIZATION, LOSS OF INSIGHT, ANXIETY,
PARANOIA, ACUTE PSYCHOSIS AND OBSESSIONAL THOUGHT CHARACTERIZED BY
DELUSIONS, HALLUCINATIONS, ILLUSIONS AND BIZARRE BEHAVIOR. DEATH IS RARE
BUT MAY RESULT FROM RESPIRATORY ARREST OR CARDIOVASCULAR COLLAPSE. EFFECTS
ON SPERMATOGENESIS IN MICE HAVE BEEN REPORTED FROM ADMINISTRATION OF A
SINGLE DOSE.
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CHRONIC EXPOSURE- REPEATED INGESTION MAY RESULT IN A LOWERING OF THE
SENSORY THRESHOLD, APATHY, DULLNESS, ANXIETY, PANIC, AGGRESSIVENESS,
DISORIENTATION, CONFUSION, CLOUDING OF MENTAL PROCESSES WITH IMPAIRED
JUDGEMENT AND MEMORY, LOSS OF PERSPECTIVE, REDUCED MOTIVATION AND
ACUTE INSECURITY. WEIGHT GAIN MAY OCCUR DUE TO APPETITE STIMULATION.
FLASHBACKS HAVE BEEN REPORTED. REDUCED T-LYMPHOCYTES AND IMPAIRED
CELL-MEDIATED IMMUNITY MAY OCCUR. TOLERANCE AND PSYCHOLOGICAL AND PHYSICAL
DEPENDENCE MAY DEVELOP WITH HEAVY PROLONGED USE. SYMPTOMS OF WITHDRAWAL
MAY OCCUR. MAY BE EXCRETED IN BREAST MILK. REPRODUCTIVE EFFECTS HAVE BEEN
REPORTED IN ANIMALS.
FIRST AID- TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION
IMMEDIATELY. IF VOMITING OCCURS, KEEP HEAD LOWER THAN HIPS TO PREVENT
ASPIRATION.
ANTIDOTE:
NO SPECIFIC ANTIDOTE. TREAT SYMPTOMATICALLY AND SUPPORTIVELY.
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REACTIVITY
REACTIVITY:
STABLE UNDER NORMAL TEMPERATURES AND PRESSURES.
INCOMPATIBILITIES:
TETRAHYDROCANNABINOL:
OXIDIZERS (STRONG): FIRE AND EXPLOSION HAZARD.
DECOMPOSITION:
THERMAL DECOMPOSITION MAY RELEASE ACRID SMOKE AND IRRITATING FUMES.
POLYMERIZATION:
HAZARDOUS POLYMERIZATION HAS NOT BEEN REPORTED TO OCCUR UNDER NORMAL
TEMPERATURES AND PRESSURES.
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STORAGE AND DISPOSAL
OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS WHEN STORING OR DISPOSING
OF THIS SUBSTANCE. FOR ASSISTANCE, CONTACT THE DISTRICT DIRECTOR OF THE
ENVIRONMENTAL PROTECTION AGENCY.
**STORAGE**
STORAGE OF CONTROLLED SUBSTANCES MUST COMPLY WITH APPLICABLE SECURITY
REQUIRMENTS IN 21 CFR 1301.71, 1301.72, 1301.73, 1301.74, 1301.75 AND 1301.76.
STORE AWAY FROM INCOMPATIBLE SUBSTANCES.
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CONDITIONS TO AVOID
MAY BURN BUT DOES NOT IGNITE READILY. PREVENT DISPERSION OF DUST IN AIR. DO
NOT ALLOW SPILLED MATERIAL TO CONTAMINATE WATER SOURCES.
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SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
DO NOT TOUCH SPILLED MATERIAL. STOP LEAK IF YOU CAN DO IT WITHOUT RISK. FOR
SMALL SPILLS, TAKE UP WITH SAND OR OTHER ABSORBENT MATERIAL AND PLACE INTO
CONTAINERS FOR LATER DISPOSAL. FOR SMALL DRY SPILLS, WITH A CLEAN SHOVEL
PLACE MATERIAL INTO CLEAN, DRY CONTAINER AND COVER. MOVE CONTAINERS FROM
SPILL AREA. FOR LARGER SPILLS, DIKE FAR AHEAD OF SPILL FOR LATER DISPOSAL.
KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY.
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PROTECTIVE EQUIPMENT
VENTILATION:
PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION SYSTEM.
RESPIRATOR:
THE FOLLOWING RESPIRATORS ARE RECOMMENDED BASED ON INFORMATION FOUND IN THE
PHYSICAL DATA, TOXICITY AND HEALTH EFFECTS SECTIONS. THEY ARE RANKED IN
ORDER FROM MINIMUM TO MAXIMUM RESPIRATORY PROTECTION.
THE SPECIFIC RESPIRATOR SELECTED MUST BE BASED ON CONTAMINATION LEVELS FOUND
IN THE WORK PLACE, MUST BE BASED ON THE SPECIFIC OPERATION, MUST NOT EXCEED
THE WORKING LIMITS OF THE RESPIRATOR AND MUST BE JOINTLY APPROVED BY THE
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH AND THE MINE SAFETY
AND HEALTH ADMINISTRATION (NIOSH-MSHA).
ANY DUST AND MIST RESPIRATOR WITH A FULL FACEPIECE.
ANY AIR-PURIFYING FULL FACEPIECE RESPIRATOR WITH A HIGH-EFFICIENCY
PARTICULATE FILTER.
ANY POWERED AIR-PURIFYING RESPIRATOR WITH A TIGHT-FITTING FACEPIECE AND
HIGH-EFFICIENCY PARTICULATE FILTER.
ANY TYPE 'C' SUPPLIED-AIR RESPIRATOR WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE OR WITH A FULL FACEPIECE,
HELMET OR HOOD OPERATED IN CONTINUOUS-FLOW MODE.
ANY SELF-CONTAINED BREATHING APPARATUS WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
ANY SELF-CONTAINED BREATHING APPARATUS THAT HAS A FULL FACEPIECE AND IS
OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE.
ANY SUPPLIED-AIR RESPIRATOR THAT HAS A FULL FACEPIECE AND IS OPERATED IN A
PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE IN COMBINATION WITH AN
AUXILIARY SELF-CONTAINED BREATHING APPARATUS OPERATED IN PRESSURE-DEMAND
OR OTHER POSITIVE-PRESSURE MODE.
CLOTHING:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE (IMPERVIOUS) CLOTHING AND EQUIPMENT
TO PREVENT REPEATED OR PROLONGED SKIN CONTACT WITH THIS SUBSTANCE.
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GLOVES:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE GLOVES TO PREVENT CONTACT WITH THIS
SUBSTANCE.
EYE PROTECTION:
EMPLOYEE MUST WEAR SPLASH-PROOF OR DUST-RESISTANT SAFETY GOGGLES TO PREVENT
EYE CONTACT WITH THIS SUBSTANCE.
EMERGENCY EYE WASH: WHERE THERE IS ANY POSSIBILITY THAT AN EMPLOYEE'S EYES MAY
BE EXPOSED TO THIS SUBSTANCE, THE EMPLOYER SHOULD PROVIDE AN EYE WASH
FOUNTAIN WITHIN THE IMMEDIATE WORK AREA FOR EMERGENCY USE.
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COPYRIGHT 1992 OCCUPATIONAL HEALTH SERVICES, INC.. ALL RIGHTS RESERVED.
CREATION DATE: 10/19/88 REVISION DATE: 10/12/92
