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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 18
1999 61
2000 82
2001 142
2002 167
2003 197
2004 174
2005 214
2006 190
2007 210
2008 212
2009 259
2010 297
2011 273
2012 269
2013 274
2014 311
2015 283
2016 264
2017 289
2018 306
2019 252
2020 256
2021 231
2022 257
2023 251
2024 88

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5,124 results

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Page 1
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.
Sun Y, Tisdale RK, Kilduff TS. Sun Y, et al. Front Neurol Neurosci. 2021;45:22-37. doi: 10.1159/000514963. Epub 2021 May 28. Front Neurol Neurosci. 2021. PMID: 34052813 Free PMC article. Review.
The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R. ...These and related compounds have also been usef …
The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are …
Orexin/hypocretin.
Kuwaki T. Kuwaki T. Peptides. 2024 Mar;173:171153. doi: 10.1016/j.peptides.2024.171153. Epub 2024 Jan 14. Peptides. 2024. PMID: 38220091 No abstract available.
Hypocretin/Orexin, Sleep and Alzheimer's Disease.
Dauvilliers Y. Dauvilliers Y. Front Neurol Neurosci. 2021;45:139-149. doi: 10.1159/000514967. Epub 2021 May 28. Front Neurol Neurosci. 2021. PMID: 34052817 Free article. Review.
New theories on the link between sleep and beta-amyloid and tau secretion, accumulation and clearance, and its interaction with hypocretins/orexins (key neuropeptides regulating wakefulness) suggest mechanistic ways to better understand the impact of sleep alteratio …
New theories on the link between sleep and beta-amyloid and tau secretion, accumulation and clearance, and its interaction with hypocreti …
Heterogeneity of Hypocretin/Orexin Neurons.
Sagi D, de Lecea L, Appelbaum L. Sagi D, et al. Front Neurol Neurosci. 2021;45:61-74. doi: 10.1159/000514964. Epub 2021 May 28. Front Neurol Neurosci. 2021. PMID: 34052814 Free PMC article. Review.
The multifunctional, hypothalamic hypocretin/orexin (HCRT)-producing neurons regulate an array of physiological and behavioral states including arousal, sleep, feeding, emotions, stress, and reward. ...
The multifunctional, hypothalamic hypocretin/orexin (HCRT)-producing neurons regulate an array of physiological and behavioral states …
Orexin/Hypocretin Signaling.
Kukkonen JP. Kukkonen JP. Curr Top Behav Neurosci. 2017;33:17-50. doi: 10.1007/7854_2016_49. Curr Top Behav Neurosci. 2017. PMID: 27909990 Review.
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX(1) and OX(2) orexin receptors, as described in the previous chapters. ...
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs) …
Eat, seek, rest? An orexin/hypocretin perspective.
Peleg-Raibstein D, Viskaitis P, Burdakov D. Peleg-Raibstein D, et al. J Neuroendocrinol. 2023 Sep;35(9):e13259. doi: 10.1111/jne.13259. Epub 2023 Mar 30. J Neuroendocrinol. 2023. PMID: 36994677 Review.
We offer a perspective on recent work suggesting how nutrient-specific neural responses shape this choice. Specifically, the hypothalamic hypocretin/orexin neurons (HONs) - cells that promote hyperlocomotive explorative behaviours - are rapidly and differentially modulated …
We offer a perspective on recent work suggesting how nutrient-specific neural responses shape this choice. Specifically, the hypothalamic …
The hypocretin (orexin) system: from a neural circuitry perspective.
Li SB, de Lecea L. Li SB, et al. Neuropharmacology. 2020 May 1;167:107993. doi: 10.1016/j.neuropharm.2020.107993. Epub 2020 Feb 6. Neuropharmacology. 2020. PMID: 32135427 Review.
Since the hypocretins/orexins were discovered more than two decades ago, extensive studies have accumulated concrete evidence showing the pivotal role of hypocretin/orexin in diverse neural modulation. ...In this review, we focus on the function of neural pat …
Since the hypocretins/orexins were discovered more than two decades ago, extensive studies have accumulated concrete evidence …
Do orexin/hypocretin neurons signal stress or reward?
Peleg-Raibstein D, Burdakov D. Peleg-Raibstein D, et al. Peptides. 2021 Nov;145:170629. doi: 10.1016/j.peptides.2021.170629. Epub 2021 Aug 17. Peptides. 2021. PMID: 34416308 Free article. Review.
Hypothalamic neurons that produce the peptide transmitters orexins/hypocretins (HONs) broadcast their predominantly neuroexcitatory outputs to the entire brain via their extremely wide axonal projections. ...
Hypothalamic neurons that produce the peptide transmitters orexins/hypocretins (HONs) broadcast their predominantly neuroexcit …
Pleasure, addiction, and hypocretin (orexin).
McGregor R, Thannickal TC, Siegel JM. McGregor R, et al. Handb Clin Neurol. 2021;180:359-374. doi: 10.1016/B978-0-12-820107-7.00022-7. Handb Clin Neurol. 2021. PMID: 34225941 Free PMC article. Review.
The hypocretins/orexins were discovered in 1998. Within 2 years, this led to the discovery of the cause of human narcolepsy, a 90% loss of hypothalamic neurons containing these peptides. ...
The hypocretins/orexins were discovered in 1998. Within 2 years, this led to the discovery of the cause of human narcolepsy, a …
Cellular Signaling Mechanisms of Hypocretin/Orexin.
Kukkonen JP, Turunen PM. Kukkonen JP, et al. Front Neurol Neurosci. 2021;45:91-102. doi: 10.1159/000514962. Epub 2021 May 28. Front Neurol Neurosci. 2021. PMID: 34052812 Free article. Review.
The Gq-PLC pathway may also, under certain circumstances, take the route to diacylglycerol lipase, which leads to the production of the potent endocannabinoid (eCB), 2-arachidonoyl glycerol, and thereby connects orexins with eCB signaling. In addition, OXRs have been studi …
The Gq-PLC pathway may also, under certain circumstances, take the route to diacylglycerol lipase, which leads to the production of the pote …
5,124 results