Erowid.org: Erowid Reference 439 : Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites : Battaglia G, Brooks BP, Kulsakdinun C, De Souza EB

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Battaglia G, Brooks BP, Kulsakdinun C, De Souza EB. “Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites”. Eur J Pharmacol. 1988;149(1-2):159-63. <a name="ref">Battaglia G, Brooks BP, Kulsakdinun C, De Souza EB.</a> <a href="/references/439">"Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites"</a> <i>Eur J Pharmacol</i>. 1988;149(1-2):159-63.
Text Abstract (this page) Full Text - English (private) Show Articles by Battaglia G Brooks BP Kulsakdinun C De Souza EB Article IDs Erowid RefID: 439 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract We report here an in vitro pharmacologic profile for MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. The rank order of affinities of MDMA at various brain receptors and uptake sites are as follows: 5-HT uptake greater than alpha 2-adrenoceptors = 5-HT2 serotonin = M-1 muscarinic = H-1 histamine greater than norepinephrine uptake = M-2 muscarinic = alpha 1-adrenoceptors = beta-adrenoceptors greater than or equal to dopamine uptake = 5-HT1 serotonin much greater than D-2 dopamine greater than D-1 dopamine. MDMA exhibited negligible affinities (greater than 500 microM) at opioid (mu, delta and kappa), central-type benzodiazepine, and corticotropin-releasing factor receptors, and at choline uptake sites and calcium channels.
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