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Pichini S, Navarro M, Farre M, Ortuno J, Roset PN, Pacifici R, Zuccaro P, Segura J, de la Torre R. 
“On-site testing of 3,4-methylenedioxymethamphetamine (ecstasy) in saliva with Drugwipe and Drugread: a controlled study in recreational users”. 
Clin Chem. 2002;48(1):174-176..
No abstract available: following summary provided Salivary MDMA was assessed in 8 individuals after the administratino of 100 mg MDMA. MDMA was detectable in saliva via the Drugwipe immunnochromatogrpahy assay and through GC-MS. No positive readings were given at 0 h (pre-drug). Drugwipe 'amphetamines' test gave positive readings to 7/8 participants at 1.5 h post-drug. Drugwipe gave positive readings to 4/8 participants 4 h post-drug, 3/8 participants at 6 h post-drug and to 2/8 participants at 10 h post-drug. The device did not provide any positive readings at 24 h post-drug. GC-MS testing detected 33756 mG of MDMA per L in soliva at 1.5 h, and 1762.7mG per L at 4 h. However, a count of positive readings in on-site Drugwipe compared to laboratory readings conducted with the Drugread device suggest that Drugwipe is more accurate when it is read with the new device (Drugread) rather than visually inspected. Though it appeared that a faint color change was visible on placebo sessions, a comparison samples taken during the MDMA session and the placebo session and read via Drugread found that the two produced significantly different readings at 1.5, 4 and 6 h after drug administration (measures either not compared or not different at 10 and 24 h post-drug). Furthermore, assays read by Drugread varied in arbitrary 'Drugread units' seemed to follow the same time-course in concentration (measured via 'units') as did salivary concentration measured via GC-MS. MDMA was the only metabolite detected in saliva with GC-MS. It would seem that the Drugwipe 'amphetamines' test is an adequate, though not perfect, means of detecting MDMA in saliva.
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