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Gastaut H, Ferrer S, Castells C, Lesevre N, Luschnat K. 
“Action de la diéthylamide de l'acide d-lysergique (LSD 25) sur les fonctions psychiques et l'électroencéphalogramme.”. 
Confinia Neurol.. 1953;13:102.
In 7 of 12 normal subjects 40-60 mcg. LSD orally produced autonomic, psychic and EEG responses. In 4 subjects only 1 or 2 of these responses were observed. In 1 case LSD had no effect. The effects are considered to be an expression of neuronic hyperexcitability (shortening of refractory period) and a reduction in the "filtering" of impulses through nervous centers.
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