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Carlsson A, Shore PA, Brodie BB. 
“Release of serotonin from blood platelets by reserpine in vitro”. 
J. Pharmacol. Exper. Therap.. 1957;120:334.
Reserpine incubated at 37degrees C with platelet-enriched plasma caused the release of 5-hydroxytryptamine from the platelets. This effect was dependent on temperature. It was appreciably lower at room temperature and almost negligible at 2 degrees C. . Only those rauwolfia alkaloids which exert reserpine-like pharmacological properties caused the release of 5- hydroxytryptamine. . LSD, chlorpromazine, phenobarbital and 48/80 did not cause the release of 5-hydroxytryptamine.
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