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Dimascio A, Suter E, Hyde RW, Greenblatt M. 
“Physiological effects of LSD: report of a detailed investigation in one subject”. 
Psychiatr. Quart.. 1957;31:57.
A systematic study was made of the physiological and psychological effects of LSD on a normal subject given 1 mcg./kg. LSD orally on 3 occasions and a placebo on 3 occasions. . Physiological and psychological adaptation to LSD occurred with repeated administration. Changes in heart rate lability, blood pressure, respiration rate and the number of sighing respirations were most pronounced on the first occasion LSD was given and decreased progressively on subsequent occasions. The psychological effects diminished concurrently.
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