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Yui T, Takeo Y. 
“Neuropharmacological studies on a new series of ergot alkaloids. Elymoclavine as a potent analeptic on reserpine-sedation.”. 
Jap. J. Pharmacol.. 1958;7:157.
The so-called agroclavine type of ergot derivatives were divided into two groups according to their effects on general behavior and motor activity in mice, rabbits, cats and dogs. . The excitor group comprised agroclavine, elymoclavine, triseclavine, penniclavine, lysergine, lysergene, lysergol and LSD. These have a double bond and produce central sympathetic stimulation. Elymoclavine was the most potent but, unlike LSD, did not increase body temperature in the rabbit. . The inhibitor group comprised dihydroagroclavine, dihydroelymoclavine and dihydroergokryptine (a component of Hydergine). These are hydrogenated derivatives and produce central depression, the effect of dihydroergokryptine being purely sedative. . Reserpine-induced sedation in mice, rabbits and cats: the analeptic effect of elymoclavine was greater than that of LSD. . Antagonism to 5-hydroxytryptamine: elymoclavine was a weaker antagonist than LSD on the rat uterus. . Reserpine-induced potentiation of barbiturate anesthesia in mice was inhibited by elymoclavine. . 5-hydroxytryptamine induced potentiation of barbiturate anesthesia in mice was enhanced by elymoclavine.
Notes # : (auch Hyg 911)
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