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Eisner BG, Cohen S. 
“Psychotherapy with lysergic acid diethylamide”. 
J Nerv Ment Dis. 1958;127:528.
Abstract
22 patients (5 inpatients and 17 outpatients) with conditions ranging from depressive states to borderline schizophrenia were given an average of 4 to 5 weekly sessions with LSD. Dosage was started at 25 mcg orally and built up in 25 mcg increments to 125 mcg. In a few instances 250 mcg were given. During the sessions one therapist was in constant attendance. During stressful periods the presence of a male and female therapist speeded the therapeutic process. Music and other aids (photographs and a mirror) were found to facilitate the action of the drug. Follow-up studies lasted 6 to 7 months. . The main criteria of improvement was continuing succession in behaviorial adaption as assessed by 3 persons (2 therapists and 1 person in close contact with the patient). Improvement was noted in 16 of the 22 cases and was not restricted to any one diagnostic category. However, patients with anxiety, compulsiveness, depressive states and anxiety with alcoholism made a good response. Inadequate schizoid personalities made a poor response. . The potential dangers of LSD (suicide or suicidal preoccupation and depression) are pointed out. Caution in the selection of patients is therefore indicated.
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