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Cahn J, Herold M. 
“Modifications du metabolisme cerebral chez le lapin in-vivo sous l'action du LSD-25 et du cardiazol. Effets de certains antagonistes du LSD-25 et du Cardiazol. [Modifications of cerebral metabolism in rabbits in vivo under the influence of LSD-25 and cardiazol. Effects of certain antagonists of LSD-25 and of cardiazol)”. 
IInd International Congress for Psychiatry, Congress Report. 1959;II:315.
The determination of various metabolites and electrolytes in carotid and v. jugularis blood of rabbits after 2 weeks of LSD treatment in comparison with controls yielded: decrease of the cerebral consumption of glucose and inorganic phosphate, diminished CO2 production, increased lactate consumption and increased glutathione reduction. This suggests the dominance of aerogenic glycolysis in spite of over-all diminution of oxidative processes (glutathione reduction as a source of energy). K loss, Ca retention. Cerebral circulation decreased. EEG: slow, high waves. . Methylandrostanolone: antagonizes the LSD effect on cerebral metabolism, except the K loss. Viadril does not influence the LSD effect on cerebral circulation and consumption of glucose but it influences the effect on the consumption of phosphate and K, restoring these towards normal. Phenothiazine-piperazyl-urea (MD-5501) intensifies the inhibition of glucose consumption and does not change the increased glutathione reduction, but it normalizes the glycolysis and the oxidative process and decreases the K loss. All 3 "LSD antagonists" inhibit the EEG changes. (See 419, 503, 512, 538, 547)
Notes # : Orig.s.Buch, Standort w.B.
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