Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Mahler DJ, Humoller FL. 
“Effect of lysergic acid diethylamide and bufotenine on performance of trained rats”. 
Proc. Soc. exper. Biol.. 1959;102:697-701.
To evaluate alterations in mental activity of rats after administration of psychotomimetic drugs, the delay in climbing a 5 foot vertical pole was measured. The rats were given solutions of LSD or bufotenine i.p. In another experiment, the effect of both psychogenic drugs was investigated after pretreatment with reserpine, 5-hydroxytryptophane (5-HTP) and iproniazid. . LSD and bufotenine prolonged the climbing time of trained rats. However, the effect of LSD wore off in about 20 minutes while that of bufotenine lasted as long as 90-120 minutes. LSD was effective in smaller doses (0.3-0.7 mg/kg) than bufotenine (9.0-27.0 mg/kg). . After several injections of LSD or bufotenine rats became refractory to the same drug; a similar cross- tolerance was observed to the other drug. . Reserpine potentiated the effect of LSD and also of bufotenine which was greater than that of one of the 2 psychogenic drugs or reserpine alone. . Treatment of rats with 5-HTP or iproniazid (increase in the brain-serotonin level) before administration of 0.5 mg/kg LSD produced a considerable decrease of response. If smaller doses of LSD (0.3 mg/kg) or bufotenine were given after 5-HPT was administered, the climbing time was longer than after LSD or bufotenine alone. . Both drugs caused confusion and behavioral changes in trained rats. The induced cross-tolerance suggests that LSD and bufotenine produce their psychogenic effect by the same mechanisms, i.e. interference with normal serotonin metabolism. Reserpine causes a release of bound serotonin in the brain and iproniazid blocks the monoamino oxidase which is probably the main pathway for normal catabolism of serotonin.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]