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Abramson HA, Rolo A. 
“Lysergic acid diethylamide (LSD-25) antagonists: chlorpromazine”. 
J. Neuropsychiat.. 1960;1:307-310.
In 22 experiments 9 nonpsychotic subjects were given 25-50 mcg. LSD or 25-50 mg. chlorpromazine (Cpz) or both orally. A questionnaire in 2 parts (questions about the physiological and perceptual state and questions of more psychological nature) had to be completed 30 minutes after ingestion of LSD and again at hourly intervals for 3 hours. The questions required "yes" or "no" answers, a positive answer indicating a change from the nondrug state. . Comparison of the number of positive answers following LSD alone, Cpz alone or LSD after premedication with oral Cpz showed that oral Cpz did not block the effect of LSD. Cpz appears to superimpose its effect upon that produced by LSD. The usual awareness of LSD psychosis was present. However, administration of Cpz before LSD caused impairment in motor behavior, drowsiness, confusion and slight depression. . The authors conclude from these experiments and from clinical observations that in some schizophrenics oral Cpz may enhance the psychotic process. Cpz therapy, therefore, should be initiated by the parenteral route "rather than orally to avoid the latent period occurring before the true tranquilizing effect of the drug is obtained". . Comment: Hoch (See 96, 230) has shown that Cpz i.m. effectively blocks the LSD reaction in man and acts at the height of the LSD reaction, while the findings of the authors indicate that Cpz administered orally produced an enhanced reaction to LSD.
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