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Silva F, Heath RG, Rafferty T, Johnson R, Robinson W.
“Comparative effects of the administration of Taraxein, d-LSD, Mescaline, and Psilocybin to human volunteers”.
Comprehensive Psychiat.. 1960;1:370-376.
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Abstract
Taraxein, a protein fraction obtained from the serum of schizophrenic patients induces, when injected i.v., schizophrenia-like symptoms in non-psychotic subjects. . In the present investigation the effects of taraxein i.v. (dose equivalent to 400 ml. serum), LSD (150 mcg. i.v. in one, orally in 2 cases), mescaline (750 mg. i.v. in one, orally in 3 cases), and psilocybin (10 mg.) orally were compared in 4 healthy volunteers in double blind and single blind experiments. .
RESULTS: The symptoms induced by taraxein, which closely approximated those seen with schizophrenia, were dysphoria, blocking and thought deprivation, delusions, anxiety, and depersonalization but there were no illusions, euphoria and hypomania and no autonomic symptoms. In contrast, LSD, mescaline and psilocybin produced symptoms usually associated with intoxication, such as disturbances in sensory perception (particularly visual distortions), euphoria, hypomania, giddiness and autonomic symptoms. Association defects, ambivalence, and depersonalization occurred with all 4 substances and anxiety and dysphoria with taraxein, LSD and mescaline (not with psilocybin), but all of these symptoms were most accentuated by taraxein. . Subjects responding intensely to one compound had marked reactions to the others, while those with mild response to one compound displayed mild response to all. No correlation with clinical appraisal of the volunteer could be drawn. The most and the least intense reactions were elicited in the two subjects who were appraised as the most unstable of the volunteer group.
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