Erowid References Database
Bertino JR, Klee GD, Collier D, Weintraub W.
“Clinical studies with dibenzyline and lysergic acid diethylamide”.
Fourteen normal male human subjects received on a double blind basis 0.16-0.51 mg/kg dibenzyline ( a sympathetic blocking agent) by intravenous infusion over a period of 60 minutes and on another occasion placebo (intravenous saline). Eleven of the 14 subjects received 1 mcg/kg LSD orally one hour after receiving dibenzyline or saline solution and 3 received placebo instead of LSD. . In 6 of the 14 subjects dibenzyline alone produced transient psychological effects varying from mild impairment of concentration and some drowsiness to more severe thought disorder, subjective numbness of the body, loss of time sense, feelings of depersonalization and unreality, and sleepiness. The effects seemed unrelated to dosage and not as intense as those of LSD. . Effects of dibenzyline on the reaction to LSD: dibenzyline did not block any effect of LSD except mydriasis and other peripheral adrenergic signs (palmer seating). Besides, the subjects were often able to sleep for the first 1 to 2 hours following LSD when premedicated with dibenzyline but never with LSD alone. Some subjects noted less anxiety than following LSD alone. . The occurrence of sedation and psychological symptoms shows that dibenzyline does have central effects but since their nature is unknown, no final conclusions can be reached regarding the role of central sympathetic stimulation in LSD reaction. . Urinary excretion of 17-hydroxycorticoids and of epinephrine and norepinephrine following both drugs was not significantly changed except for that of epinephrine following dibenzyline.
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