Erowid References Database
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Lew R, Sabol KE, Chou C, Vosmer GL, Richards J, Seiden LS.
“Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies”.
J Pharmacol Exp Ther. 1996 Feb;276(2):855-65.
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Abstract
In our study, age-matched Holtzman Sprague-Oawley rats (275-300 g) received injections with either saline (0.9%) 3,4-methylenedioxymethamphetamine (MDMA; 20 mg/kg free base s.c) twice daily for 4 days and allowed to recover for 2, 8, 16, 32 and 52 wk after the final injection before death. Radio-ligand binding studies with _251-RTI-55 to dopamine uptake sites in striatal homogenates showed no effect of MDMA on the density of dopamine uptake sites. In contrast, saturation binding studies with _251-RT1-55to 5-HT uptake sites in hippocam- pal and frontal-parietal homogenates showed a significant reduction in the number of uptake sites at 2 wk after MDMA treatment (34 and 25%, respectively of controls). By 16 wk, partial recovery in the number of 5-HT uptake sites was observed in both tissues; however, only a full recovery of serotonin uptake sites was observed in hippocampus at the end of 52 wk. In more detailed studies using autoradiography with 125 I-RTI-55, recovery of serotonin uptake sites varied from region to region.
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