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Morgan JF. 
“Toxic effect of MDMA on brain serotonin neurons”. 
Lancet. 1999 Apr 10;353(9160):1268-9; discussion 1.
Sir--The landmark study by U D McCann and colleagues provides convincing evidence of an association between decreased serotonin transporter binding sites and MDMA use. Nonetheless, it is important to note that this study does not allow comment on causal relations, and McCann and co-workers are over-eager to wring meaning from their findings. The investigators briefly consider that MDMA users may pursue such use as a result of pre-existing serotonin function abnormalities, only to dismiss this on the grounds that 'none of the MDMA users had a neuropsychiatric disorder in which serotonin has been implicated'.
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