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Weidmann H, Taeschler M, Konzett H. 
“Zur Pharmakologie von Psilocybin, einem Wirkstoff aus Psilocybe mexicana Heim”. 
Experientia. 1958;14(10):378.
Psilocybin, the active principle of Psiloybe mexicana Heim, exerts no typical effects in vitro, but exerts characteristic effects in vivo: mydriasis, piloerection, tachycardia, tachypnoea, hyperthermia, hyperglycemia, an increase in blood pressure and contraction of the nictitating membrane. These effects are mostly due to central stimulation of sympathetic structures. Direct evidence of a central action is offered by the alerting effect in the EEG and the enhancement of spinal reflexes.

In contrast to these stimulating effects, motor activity tends to be slightly depressed.

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