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Delay J, Pichot P, Lempérière T, Nicolas-Charles P, Quétin AM. 
“Les effets somatiques de la Psilocybine”. 
Presse méd.. 1959;67:1368.
Psilocybin is one of the active principles of certain hallucinogenic Mexican mushrooms. It is the first phosphorylated indole compound that has been discovered in nature. Moreover, it is the first tryptamine derivative with a hydroxyl group in position 4 of the indole system that has been discovered in nature. Psilocybin has close structural relationships with naturally occurring hydroxytryptamine derivatives like serotonin, bufotenin and bufotenidin which are of biochemical importance. It is also related to psychotropic indole alkaloids like tabernanthine, harmine and reserpine. . The authors investigated the action of Psilocybin in 13 healthy volunteers (11 men, 2 women) and in 30 patients. . Somatic effects of the drug are mydriasis, vasomotor disturbances, changes in heart rate, blood pressure and reflexes. . The major somatic effects are similar in normal subjects and mental patients. However, certain symptoms (asthenia, somnolence, cephalgia, trembling, yawning, digestive upsets) are decidedly more common in healthy subjects. Normal individuals are doubtless more sensitive than mental patients to minimal changes in their physiological equilibrium. The difference between the two groups can probably be explained in part by the fact that the healthy subjects are more accurate in their observation. . Unlike other psychodysleptics (mescaline, LSD) Psilocybin is inclined to produce a fall in blood pressure and bradycardia. This difference contrasts with the psychic actions of all these drugs which, superficially at least, are similar.
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