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Quétin AM.
“La Psilocybine en psychiatrie clinique et expérimentale”.
Doctoral Thesis. 1960 Jun 10.
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Abstract
Administration of Psilocybin orally (average dose 9.26 mg.), s.c. (average dose 8.36 mg.) or i.m. (average dose 9.07 mg.), to 32 healthy persons aged 25-35 and 68 psychiatric patients aged 16-66 (21 schizophrenics, 6 with chronic delusions, 6 manic-depressive psychoses, 6 oligophrenics, 29 neuroses including 3 alcoholics). . Thorough analysis revealed the following properties of psilocybin: . 1. The effect of Psilocybin is comparable with that of LSD and Mescaline but differs in the somatic manifestations producing bradycardia, hypoglycemia, no change in leucocyte count; in the psychic sphere it releases suppressed memories. . 2. The mode of action is complex and not yet clarified: the chemical relations to LSD-25 and serotonin are interesting. . 3. The drug is certainly of interest for diagnosis and probably also for psychotherapy (studies are currently in progress in Professor Delay's clinic.) . 4. The reaction of healthy subjects can sometimes be predicted if the type of personality is known: psychometric studies should be done.
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