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Hollister LE. 
“Clinical, biochemical and psychologic effects of Psilocybin”. 
Arch. internat. Pharmacodyn.. 1961;130:42-52.
Psilocybin was given to 7 volunteers in 9 trials, in doses of 60-209 mcg/kg orally; 9 volunteers received on separate occasions Psilocybin 60-209 mcg/kg orally and 37-205 mcg/kg subcutaneously. In most of these cases the same doses were given orally and parenterally. To assess clinical effects, subjective experiences were recorded and a questionnaire was used; in addition, psychometric tests were applied and several biochemical and clinical measurements were made. . Prominent symptoms produced by Psilocybin were dizziness, weakness, nausea, anxiety, visual effects, dreamy states and impaired coordination. Pupillary dilation and increased deep tendon reflexes were rather constant signs. Urinary excretion of inorganic phosphorus and total circulating eosinophils were significantly reduced. Performance of psychometric tests was decreased for 1-2 hours after the drug, possibly due to decreased motivation. The clinical syndrome produced by parenteral administration of Psilocybin lasted slightly longer. . Chronic administration of Psilocybin in one case (increasing doses of 1.5 mg. to 27 mg. in 21 days) led to temporary tolerance, 15 mg. (203 mcg/kg) given on the 22nd day had almost no effect, while several weeks later the same dose produced the characteristic clinical syndrome. . Many effects of Psilocybin resembled those of LSD, but the duration of action was shorter. Somatic effects were less severe even though accompanied by dreamy, ruminative, and introspective periods. The author believes that Psilocybin may be useful and preferable to LSD for facilitating psychotherapy.
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