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Böszörményi Z.
“Psilocybin and diethyltryptamine: two tryptamine hallucinogens”.
Neuro-Psychopharmacology. 1961;2:226-229.
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Abstract
Twenty-eight normal subjects and 24 patients (11 schizophrenics, 5 hysterics and 8 neurotics) received Psilocybin. Half the subjects were given 6-11 mg. (average 9 mg.) Psilocybin orally, and the other half the same doses by intramuscular injections. Eighteen of the 28 normal subjects as well as 3 psychotics and 3 neurotics had received diethyltryptamine (DET) 1/2-1 year earlier. Three subjects received 15 mg. amphetamine i.v. at the height of the Psilocybin reaction. . The characteristic syndrome produced by Psilocybin is described in detail. . While Psilocybin seemed to suspend the control activity and produced diffuse excitation, DET seemed to stimulate cerebral structures responsible for coordination of personality, self-control, etc. . Response to oral Psilocybin resembled more the effect of DET; however, differences with i.m. Psilocybin were more marked. Psilocybin i.m. produced a tendency to introversion. The response to Psilocybin plus amphetamine resembled the DET effect. . Psilocybin appeared to be more useful in the treatment of obsessional neurosis because it caused a remarkable "mellowing" of exaggerated self-control and an increased affective resonance. In cases of neurosis it may be more favorable in bringing suppressed material to the surface. DET was better in breaking through a stupor. In 1 catatonic and in 1 case of hysteric autism DET successfully resolved mutism. . The pre-experimental life situation is of decisive importance and should also be considered in the assessment of psychotogenic drugs.
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| Notes # : Proceedings of the 2nd International Meeting of the collegium Internationale Neuro-Psychopharmacologicum, Basle 1960 |
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