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Yamada K, Ogawa N, Gomita Y, Fujiwara M, Ueki S. 
“State-Dependent Learning (Dissociation of Learning) with Hallucinogens in Rats.”. 
Jap.Pharmacol.. 1973;23(Suppl):66.
The effects of delta-9-tetrabydrocannabinol (THC), mescaline, LSD-25 and methamphetamine on the learning of passive and/or active avoidance were studied in rats. Rats were trained in passive avoidance task and retested for retention of the acquired response 24 hr later. The rats were given i.p. either one of hallucinogens or saline 30 min before the test. THC (5 mg/kg) or mescaline (25 mg/kg) given before training significantly decreased retention, or dissociated learning, of passive avoidance response. However, THC or mescaline given before both training and retest, or only before retest, gave no retention deficit. High doses of THC (10 mg/kg) and mescaline (50 mg/kg) caused a marked retention deficit from a drugged to a non-drugged state in the drug-saline group. THC and mescaline, therefore appeared to cause a partial and an asymmetrical dissociation of learning. LSD-25 (100 mcg/kg) and methamphetamine (2 mg/kg) produced no retention deficit between drugged and non-drugged states. Furthermore, rats trained for conditioned avoidance responding in a two-compartment shuttle box after THC exhibited no transfer when tested in the non-drugged state. The THC group exhibited an impairment of the acquisition, as compared with the control group. In conclusion, THC and mescaline induced state-dependent learning while LSD-25 and methamphetamine did not.
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