Erowid References Database
Ziegler MG, Lovell RA, Freedman DX.
“Effects Of Lysergic Acid Diethylamide On The Uptake And Retention Of Brain 5-hydroxytryptamine In Vito And In Vitro”.
The effects of D-lysergic acid diethylamide (LSD) and other drugs on brain.5 - hydroxytryptamine (5-HT) in viva and in Biro and on 3H-5-HT administered intraventricularly have been studied in male Sprague-Dawley rats. The results in vivo. show that the retention of 3H-5-HT in the brain is increased by treatment (i.p.) with LSD and p-chlorophenylalanine (PCPA) and decreased by reserpine. This LSD effect in viva can be reversed by intraventricular ouabain (given together with 3H-5-HT) in amounts which cause brief convulsions. In vitro, LSD added to the medium initially (0-10 min) decreased uptake of 3H-5-HT in brain slices but enhanced its retention at 60 min. These effects of LSD were not observed either after pargyline treatment. (i.p.) or in the presence of pargyline in vitro. These results are consistent with the idea that LSD decreases 5-HT turnover through an inhibition of neuronal firing, which can be overcome by neuronal depolarization sufficient to cause convulsions. It is suggested that the decreased 5-HT turnover seen after LSD is somehow mediated ' by a mechanism which protects 5-HT from deamination by monoamine oxidase, and that an effect on 5-HT uptake may be a mechanism involved in the interaction of LSD with brain 5-HT.
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