Erowid References Database
“Analysis Of The Influence Of Selected Neurotropic Agents On Hepatic Metabolism In Relation To Endotoxicosis”.
Biochem. Pharmacol.. 1974;23:2577-2584.
A number of neurotropic agents were tested For influence on hepatic metabolism in relation to their ability to alter sensitivity to bacterial endotoxin which is known to derange both neurotransmission and also the homeostasis of selected functions in the liver. . Like endotoxin, dihydroxyphenylalanine (DOPA) lowered hepatic tryptophan pyrrolase (TP) activity within 6 hr and this effect was specific since neither of the two other analogues parachlorophenylalanine (PCPA) and phenylalanine, nor serotonin and LSD-25, depressed the hepatic TP. The LSD-25 or PCPA, but not phenylalanine, DOPA or serotonin, increased hepatic tyrosine transaminase (TT). Contrary to endotoxin, neither agent lowered liver glycogen levels in 4 hr but them decreased 18 hr after phenylalanine or LSD-25. HgCI2, which alters host response to endotoxin lethality like PCPA, increased the endogenous TT and TP activities, decreased liver glycogen, and permitted residual induction of these functions by exogenous hormone. The organic mercurial PCMB (which only minimally alters endotoxin toxicity) was less toxic than HgCI2 for these hepatic functions. The uptake and distribution of cortisone were not altered by either mercurial. These results, in conjunction with those on the lethal effects of endotoxin, indicate the need to reconsider the molecular mechanisms of endotoxic reactions.
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