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Cheek FE, Holstein CM.
“Lysergic acid diethylamide tartrate (LSD-75) dosage levels, group differences, and social interaction.”.
J.nerv.ment.Dis.. 1971;153:133-147.
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Abstract
Four exploratory studies of the effects of lysergic acid diethylamide tartrate (LSD-25) on social behaviors (measured with the Bales Interaction Process Analysis) showed definite changes in all subject groups. The interaction of 4 4 person continuing groups, including a group of reformatory inmates, 2 groups of alcoholics, and a group of chronic schizophrenics, was examined in drug and placebo sessions. For 3 groups, the reformatory inmates, one group of alcoholics, and the group of schizophrenics, dosages of 25, 50, 75, and 100 micrograms were administered. For the second group of alcoholics, dosages of 100 and 200 micrograms were given and the interaction was studied in both morning and afternoon sessions. Some changes were related to dosage level and were similar across groups. For instance, total in-teraction rose at lower dosages, seemed to level out at slightly higher dosages, and decreased at the high dosage administered. However,some changes with dosage level appeared to reflect the composition of the group. For example, the behaviorally aggressive reformatory inmates showed increased negative social emotional behaviors, the 2 alcoholic groups rose in positive social emotional behaviors, while the schizophrenics tended to rise in both positive and negative behaviors with rising LSD dosages. Self-analytic behavior rose markedly at the higher dosages, but only in the alcoholic group, which received 100 and 200 micrograms so that it was unclear whether group composition was signifi-cant in this case. These dosage and group compostion related findings served to explain some contradictory findings of earlier studies and sug-gest important implications for both the therapeutic and illicit uses of LSD-25. 13 references. (Author abstract modified)
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