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Yamada K, Ogawa N, Ueki S. 
“State-Dependent Learning (Dissociation of Learning). III. State-Dependent Learning with Hallucinogens in Rats.”. 
Jap J Pharmacol. 1974;24(Suppl):52.
The term 'state-dependent learning' refers to the absence of transfer of a trained response between two physiological states. The Authors previously reported that 9 - tetrabydrocannabinol (THC) and mescaline induced state dependent learning, whilst LSD - 25 and methamphetamine failed to do so in passive and active avoidance in rats (Jap.J.Pharmacol., vol.23, suppl. 10i, 1973), The objective of the present investigation was to study whether these drugs have a similar dissociative action upon habituation to open - field behavior. Open-field behavior of male Wistar King A rats was studied for a 3 min session each day for 16 days. D-S Group was injected (i.p.) with a hallucinogen for the first 14 sessions and saline for the last 2 sessions, whilst-the drug sequence was reversed for S-D group and S - S group was given saline only for all'l6 sessions. In D-S groups, THC (5 mg/kg) slightly lowered ambulation and rearing, and also caused walking backwards, while mescaline (25 mg/kg), LSD-25 (100 mcg/kg)and methamphetamine (2 mg/kg) markedly enhanced ambulation and rearing as compared with those of S-S group during 14 sessions. The intersession habituation was somewhat gradual regarding ambulation in 5 experimental groups. Additionally, the 4 D-S groups, subjected to state change in session 15 and 16, showed a fall in ambulation as compared with those with no state change, whilst saline - THC group showed a slight fall in ambulation and the other S-D groups showed a rise. The drugs studied produced state-dependent behavior in the sense that dissociation or state dependency is defined as variation in habituated responses due to state change.
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