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Aghajanian GK, Haigler HJ, Bloom FE. 
“Lysergic Acid Diethylamide And Serotonin: Direct Actions On Serotonin-containing Neurons In Rat Brain”. 
Life Sci. 1972;11(Part I):615-622.
Lysergic acid diethylamide (LSD) and'serotonin (5HT) were applied directly by microiontophoresis to 5HT-containing neurons in the midbrain raphe nuclei. The firing of these neurons was markedly inhibited by both LSD and 5HT. The effects of LSD given systemically and microiontophoretically were similar. This suggests that the inhibition of raphe neurons which occurs after the systemic administration of LSD could be due to a direct action of the drug.
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