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Barfknecht CF, Nichols DE, Rusterholz DB, Long JP, Engelbrecht JA, Beaton JM, Bradley RJ, Dyer DC. 
“Potential Psychotomimetics. 2-Amino-1,2,3,4-tetrahydronaphthalene Analogs”. 
J Med Chem. 1973;16:804-808.
The synthesis of 2-amirio-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene (5,8-AD') and evaluation of ADT and 2-amino-1,2,3,4-tetrahydronaphthalene (2-AT) as partial congeners of LSD and restricted conformers of psychotomimetic phenylisopropyiamines were undertaken. Theoretical aspects of psychotomimetics are discussed; Both compounds depressed spontaneous motor activity in mice and had a presser effect in the anesthetized dog. In the Sidman avoidance test in rats, 2-AT was probably hallucinogenic, while 5,8-AD had only an amphetamine-like, stimulatory effect. In the isolated rat fundus strip, 2-AT caused contraction and was antagonized at low doses by BOL. Agonistic effects were not seen for 5,8-AD.
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