Erowid References Database
Domino EF, Bartolini A.
“Effects of various psychotomimetic agents on the EEG and acetylcholine release from the cerebral cortex of brainstem transected cats”.
The effects of the i.v. administration of delta9 - tetrahydrocannabinol (THC), phencyclidine, the pyrrolidyl and piperidyl isomers of Ditran, and LSD-25 on the spontaneous neocortical EEG and the release of acetylcholine (ACh) from the soma - torsensory cortex 'was studied in 18 brainstem - transected cats. In- doses of 0.5mg/kg or greater, THC produced close 'related neocortical high volt - age EEG slow waves and a reduction in arterial blood pressure and heart ' rate.- In doses of 0.5mg/kg, THC produced either no effect or a slight increase in the release of ACh from the cor - tex; larger doses caused a progressive decrease in ACh release. The effects of THC on the EEG' and the release of ACh were antagonized by (plus) - amphetamine. Phencyclidine in doses of 1mg/kg i.v.' caused marked EEG changes and a slight in - crease in the release of ACh; in doses of 5mg/kg, ' it caused pronounced EEG changes but did not significantly depress ACh release. Pentobarbital (20mg/kg) dramatically reduced ACh release. Both isomers of Ditran - (1mg/kg) slowed the EEG and dramatically ' increased the release of cortical ACh. LSD-25 usually caused EEG high voltage, slow waves, and a decrease in arterial blood pressure. Its effects on ACh release were only -moderate and depended upon basal release levels. It is concluded that various hallucinogens 'dif - ferentially affect the neocortical release of ACh in pretrigeminai rnidpontine transected cats. Gross EEG neocortical changes were not directly corre - lated with the cortical release of Ach per se. 25 references. (Author abstract modified)
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