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Goldman H, Fischer R. 
“Cortical and or Subcortical Effects as a Function of Hallucinogenic Drug Structure”. 
Pharmacologist. 1974;16(2):237.
LSD displays (1) the 2-aminotetralin conformation found in mescaline, cyclazocine and catecholamines and (2) the 4-substituted tryptamine structure of psilocybin which is a serotonin analog. Hence, cross-tolerance between LSD and cyclazacine is predicted but not between mescaline and psilocybin. Although 'LSD binds subcortically, its effect on regional per-fusion of the brain and, presumably, function is primarily cortical and, since the perfusion shifts evoked by psilocybin are confined to subcortical 'regions, it is predicted that other compounds with the 2-amino-tetralin structure, such as mescaline, may also selectively affect cortical activity.
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