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Griffith JD, Nutt JG, Jasinski DR. 
“A comparison of fenfluramine and amphetamine in man”. 
Clin Pharmacol Ther. 1975;18:563-570.
dl-Fenfluramine hydrochloride (60 120. 240 mg) d-amphetamine sulfate (20 40 mg) and placebo were compared in 8 postaddict volunteers each dose given orally in random sequence at weekly intervals using a double-blind crossover design. Fenfluramine had little effect on blood pressure and temperature but caused a marked dilation of pupils whereas amphetamine was a potent vasopressor anti a Bleak mydriatir. While fenfluramine produced euphoria in sonic subjects its overall effects were unpleasant sedative and qualitatively different from amphetamine. Three subjects given 240 mg of fenfluramine experienced brief but vivid hallucinogenic episodes characterized by olfactory visual and somatic hallucinations abrupt polar changes in mood thne distortion fleeting paranoia and sexual ideation. These observations indicate that fenfluramine is a hallucinogenic agent with a pharmacologic profile in man that is not amphetamine-like.
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