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Marquis W J. 
“A Behavioral Analysis of Hallucinogenic Drugs”. 
Dissertation Abstr. Intern. B. 1975;35(9):4572-4573.
A behavioral analysis of hallucinogenic drugs was described. A differentiation on the basis of effects on operant conditioning programs using rats can be made between 2,5-dimethoxy-4 - - methylamphetamine (DOM) and LSD and psilocybin. The effect of DOM on DRL, HI and Sidman-Avoidance paradigms was similar to that of d-amphetamine over a wide dose range, but at the highest dose tested in DRL and FI paradigms, DOM was similar in activity to LSD and psilocybin. Cross tolerance was observed between DOM and d-amphetamine on both FRY and HI paradigms. AMPT attenuated the effects of DOM or d - amphetamine on the Sidman-Avoidance response in an identical fashion. AMPT failed to attenuate the pause induced by DOM on an FR schedule, while cinanserin did. LSD and mescaline rapidly induce tolerance on an FR-40 schedule, while tolerance to DOM, dimethyltryptamine (DMT) and d-amphetamine only develops after a longer period of repeated daily injections. Larger doses of hallucinogenics consistently prolonged tolerance development. Tolerance developed on DRL and FR paradigms but not on the shock avoidance schedule. Cinanserin was an effective antagonist of mescaline, DMT, LSD, DOM and psilocybin for the hallucinogenic pause in FR performance . A 5-HT receptor antagonist role for hallucinogenic drugs was not supported by these studies. Hallucinogenic drugs may induce, directly or indirectly, an excessive activation of 5-HT receptors on the serotonergic raphe neurons projecting to the limbic fore - brain, suppressing the firing rate of the raphe cells. The applications of these studies to the testing of endogenous compounds implicated in the etiology of psychosis were considered.
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