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Park GB. 
“The Application Of Electroanalytical Techniques To Biochemical Systems”. 
Diss Abstr. Intern. B. 1974;34(12):5849-B.
Voltammetry and chronocoulometry were applied to three distinct problems, one each in neurochemistry, pharmacology, and clinical chemistry.Uric acid is presently analysed using a spectrophotometric determination based on the formation of the blue color of tungsten blue. Although most of these assays are done in conjunction with automatic analysers, a considerable number are done by hand, a process which can be quite time-consuming, and the results obtained are not normally equivalent to the results ob - tained using the same assay with the automatic analyses. A new method for the analysis of uric acid using chronocoulometry is described which requires no sample preparation, no reagents, and the uric acid concentration is read out digitally in four seconds. The results show good correlation with those obtained using the Technicon 12/60 AutoAnalyser. The often-alluded-to protective system of the brain toward catecholamines was studied and substantiated in vitro by elec - trochemically following the air oxidation of norepinephrine, dopamine and 6-hydroxydopamine with and without-the presence of rat brain slices. The possible protective capacity of ascor - bic acid, glutathione, acetylcholine, serotonin, and superoxide dismutase was also studied. Brain tissue and ascorbic acid are shown to protect catecholamines for long periods of time but are shown to have little or no effect on the rate of air oxidation of 6-hydroxydopamine at physiological pH. A preliminary study of the utility of electrochemical methods of analysis for phencyclidine and LSD is presented. It is shown that these methods can be useful in the quantitation of drug samples from the street. Evidence is also presented suggesting the possible use of electrochemistry for the anal - ysis of samples containing mescaline and/or methadone.
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